PMID: 3750371Jan 1, 1986Paper

Hemodialysis clearance of chloroquine in uremic patients

Therapeutic Drug Monitoring
A AkintonwaA F Mabadeje

Abstract

The hemodialysis blood clearance of chloroquine was studied in four patients with chronic renal failure undergoing chronic hemodialysis. The patients were administered chloroquine (600 mg base) orally after a light breakfast. Blood samples were then obtained from arterial blood entering and venous blood leaving the dialysis machine at 0.0, 0.5, 1.0, 2.0, 4.0, and 6.0 h, and at 24.0 and 48.0 h post dialysis. The blood flow rate varied between 200 and 275 ml/min, while the dialysate flow rate was maintained at 500 ml/min. The samples were analyzed for chloroquine by high pressure liquid chromatography, and the dialysis clearance was calculated utilizing the formula: ClD = QB[(CA - CV)/CA]. The mean extraction ratios for chloroquine were 0.238, 0.317, 0.207, and 0.216 in the four patients during the 6-h dialysis period. The calculated dialysis clearances were 57.2, 77.0, 56.1, and 48.3 ml/min. Chloroquine hemodialysis clearance was 14.5% of total body clearance in normal subjects and in patients with chronic renal failure not on hemodialysis.

Citations

Feb 2, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sabine AmetGilbert Deray
Jun 1, 1989·British Journal of Clinical Pharmacology·S E TettK F Brown
Mar 1, 1994·Journal of Clinical Pharmacology·S M TangeP E Senécal
Apr 20, 2020·Clinical Pharmacokinetics·Cornelis SmitCatherijne A J Knibbe
Jul 30, 2020·Clinical Pharmacokinetics·Markus ZeitlingerUNKNOWN PK/PD of Anti-Infectives Study Group (EPASG) of the European Society of Clinical Microbiology, Infectious Diseases (ESCMID)
Sep 24, 2020·Journal of the American Society of Nephrology : JASN·Ingrid BerlingUNKNOWN EXTRIP workgroup
Oct 17, 2020·Critical Care Explorations·Weerachai ChaijamornNattachai Srisawat

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