Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia

Kidney International
John T Daugirdas, Angelito A Bernardo

Abstract

Substantial activation of platelets can occur in the course of hemodialysis. Platelet surface markers show evidence of platelet degranulation. Some activation occurs due to exposure of blood to the roller pump segment and microbubbles may play a role. Platelet activation seems to be reduced with reused dialyzers or with those containing synthetic versus cellulosic membranes. Nevertheless, a substantial degree of platelet activation can be demonstrated with polysulfone and other synthetic membranes; the amount of activation may differ substantially among polysulfone membranes, depending on the manufacturer and the polyvinylpyrrolidone content. Platelet-platelet and platelet-leukocyte aggregates have been detected in the dialyzer blood outflow line and the consequences of these to the microcirculation are unknown. Typically, the platelet count decreases slightly during the first hour of dialysis, but mostly returns to initial values by the end of dialysis. A number of chronic hemodialysis patient cases have been reported in which a marked decrease in platelet count (50% or more) during dialysis was observed, resulting in mild degrees of predialysis thrombocytopenia. In only one case was the decrease in platelet count associated w...Continue Reading

References

Aug 1, 1992·Kidney International·J E TaylorJ J Belch
Nov 1, 1987·American Journal of Hematology·A M Shojania, G Turnbull
Jun 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·F Knudsen, J Dyerberg
Jan 1, 1988·Blood Purification·D von HerrathF Dati
Apr 1, 1985·The American Journal of Medicine·R M Hakim, A I Schafer
Jan 1, 1983·American Journal of Nephrology·S L VicksG W Schmitt
Apr 1, 1982·Seminars in Thrombosis and Hemostasis·Robert M Lindsay, W F Clark
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S K MujaisH J Gurland
Aug 1, 1994·Kidney International·Meinrad GawazH J Gurland
Jan 1, 1994·Blood Purification·A GutierrezL W Henderson
Jan 1, 1994·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M K DewanjeeG N Sfakianakis
Jan 1, 1995·American Journal of Nephrology·V BonominiS Stefoni
Jan 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J E RomâoM Marcondes
Feb 9, 1999·Artificial Organs·M BonominiN Settefrati
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·R E Drews, S E Weinberger
Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P LeitienneM Laville
Mar 10, 2001·Journal of Vascular Surgery·M SobelY Suda
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Atul AggarwalDavid J Schneider
Aug 8, 2002·Biomaterials·Nicholas A Hoenich, Kostas P Katopodis
Mar 20, 2003·Journal of the American College of Cardiology·Shamir R Mehta, Salim Yusuf
Jul 29, 2005·Artificial Organs·Pavlina ZemanovaFrantisek Sefrna
Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mareille GrittersMenso J Nubé
Sep 30, 2005·Hemodialysis International·Robert C Yang, Robert M Lindsay
Oct 21, 2005·Chest·Michal Barak, Yeshayahu Katz
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vin-Cent WuPo-Ren Hsueh
Mar 24, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrew Davenport
Apr 21, 2006·Hemodialysis International·Karel OpatrnýJörg Vienken
Jun 9, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Masahiro MiyataAkinobu Gotoh
Jun 15, 2006·Pathophysiology of Haemostasis and Thrombosis·Miso SabovicJadranka Buturovic Ponikvar
Oct 20, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Detlef H KrieterChristoph Wanner
Jul 11, 2007·Journal of Materials Science. Materials in Medicine·Bai-hai SuChang-sheng Zhao
Mar 28, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mareille GrittersMenso J Nubé
Jan 10, 2009·Artificial Organs·Ansgar ErlenkötterJörg Vienken
Mar 25, 2009·Expert Opinion on Drug Safety·Theodore E Warkentin, Andreas Greinacher
Jun 13, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Manal F ElshamaaAmira Helmy
Jun 30, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mareille Gritters-van den OeverMenso J Nubé
Jul 29, 2009·Nature Reviews. Nephrology·Samaha Syed, Robert F Reilly
Oct 2, 2009·International Urology and Nephrology·Emna El Golli-BennourAddellatif Achour
Dec 17, 2009·Hematology·James N George, Richard H Aster
Jan 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·James B Post
May 7, 2011·Case Reports in Medicine·Feyisayo OlafiranyeOladipupo Olafiranye
Jun 30, 2011·Hemodialysis International·Maria Aurora PosadasJames Paparello
Oct 20, 2011·JAMA : the Journal of the American Medical Association·Mercedeh KiaiiJennifer MacRae

Citations

Oct 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karthik TennankoreChristopher Chan
Oct 24, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Saeko NishimiShoichi Chida
Nov 26, 2013·Critical Care Nursing Clinics of North America·Edythe M Greenberg, Elizabeth S Sue Kaled
Mar 7, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georg SchlieperNikolaus Marx
Jan 25, 2013·Kidney International·John T DaugirdasFHN Trial Group
Apr 10, 2014·Artificial Organs·Zenib AljadiJoachim Lundahl
Apr 17, 2014·Seminars in Dialysis·John T Daugirdas
Jul 30, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Annelies E de WeerdMichiel G H Betjes
Apr 13, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael V RoccoFHN Trial Group
Apr 19, 2016·Internal Medicine·Eri KobariMasaaki Nakayama
Jan 16, 2015·BMC Nephrology·Kiran P SatheKar-Hui Ng
Mar 7, 2014·Clinical Kidney Journal·Marianne SchoorlMenso J Nubé
Jul 19, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Samar Ahmed, Assem El-Sherif
Oct 16, 2016·BMC Nephrology·Gergely BecsJános Kappelmayer
May 24, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hale Unal AksuNevzat Uslu
Apr 2, 2014·The Annals of Pharmacotherapy·Jonathan F MailmanDan Martinusen
Feb 28, 2017·Nature Reviews. Nephrology·Kristina N EkdahlBo Nilsson
Feb 21, 2018·Platelets·Michaela FinsterbuschAlice Assinger
Nov 10, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Solbjørg SagedalPer Morten Sandset
Oct 4, 2018·The International Journal of Artificial Organs·Shinya ChiharaMichiaki Yamakage
Oct 4, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ikuto Masakane, Kenji Sakurai
Nov 10, 2018·Hemodialysis International·Konomi TogoAkihiro C Yamashita
Nov 16, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Justin LeeJawed Fareed
Feb 10, 2018·Scientific Reports·Floris VanommeslaegheSunny Eloot
Oct 30, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Qiaoyan GuoPing Luo
Jan 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang ShanZhi Ping Xu
Sep 18, 2020·International Urology and Nephrology·Malvinder S Parmar
Oct 11, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ryan McMillanJawed Fareed
Mar 19, 2019·Critical Care Medicine·Anne-Cornélie J M de Pont, Meint Volbeda
Nov 7, 2019·Journal of Thrombosis and Thrombolysis·Philipp MourikisAmin Polzin
Feb 15, 2013·The International Journal of Artificial Organs·Vassilis FiliopoulosDimosthenis Vlassopoulos
Apr 9, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Masahiro MiyataKoichi Umimoto
Dec 23, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Steven KimShuvo Roy
Jun 2, 2017·The International Journal of Artificial Organs·Claudio RoncoAlberta Alghisi
Aug 2, 2017·Hemodialysis International·Kamonwan TangvoraphonkchaiAndrew Davenport
Aug 5, 2017·The International Journal of Artificial Organs·Masashi TagayaKazunobu Hara
May 7, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Konomi TogoAkihiro C Yamashita
Oct 21, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Nordeval Cavalcante Araújo, José Hermógenes Rocco Suassuna
Nov 18, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kinue KamataToshinori Koizumi
Dec 29, 2016·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Edythe M Greenberg
Mar 4, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Irene Faria DuayerRosilene Mota Elias

Related Concepts

UDEL
Indirect Thrombin Inhibitors
Blood Platelets
Medical Device Design
Hemodialysis
Liquaemin
Kidney Diseases
Membranes, Artificial
Platelet Adhesiveness
Platelet Aggregation

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.