Hemodialysis with cuprophane membrane modulates interleukin-2 receptor expression

Kidney International
P M ZaouiR M Hakim

Abstract

Chronic dialysis patients have several indices of immune deficiency. We examined the hypothesis that the biocompatibility of dialysis membranes may influence the ability of lymphocytes to express interleukin-2 (IL-2) receptors on their surface, a key event in cellular immune response. We investigated the potential role of the dialysis membrane in eight chronic hemodialysis patients. The study design was a cross-over study using cuprophane and polymethylmethacrylate (PMMA) membranes. Chronic dialysis with new cuprophane membrane leads to an increase in baseline expression of the two subunits of IL-2 receptors. IL2R alpha (p55, CD25) and IL-2R beta (p70), in peripheral blood mononuclear cell (PBMC). However, Phytohemagglutinin (PHA) stimulation of PBMC harvested after two weeks of dialysis with cuprophane membrane showed a markedly decreased expression of high affinity IL-2 receptors. These findings are reversed when patients were dialyzed with a PMMA membrane which is also associated with minimal complement activation. The increased expression of IL-2 receptor subunits are reproduced in vitro by direct contact of PBMC with cuprophane membrane and by the addition of the anaphylatoxin C5a. This study confirms the participation of ...Continue Reading

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Citations

Jun 25, 1998·Journal of Biomedical Materials Research·I M KhouwM J van Luyn
Apr 17, 2004·Kidney International·Carmelo LibettaAntonio Dal Canton
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M Lazarus, W F Owen
Sep 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H RabbG Ramirez
Sep 1, 1993·Kidney International·R M Hakim
Apr 1, 1993·Kidney International·B Descamps-LatschaJ Zingraff
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I C van Riemsdijk-Van OverbeekeW Weimar
Jun 12, 2019·International Journal of Clinical Oncology·Chen XiaoHongZhang Boheng
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Jerome SampolRegis Guieu
Apr 20, 2000·Journal of the American Society of Nephrology : JASN·Alejandro Martín-MaloPedro Aljama
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·B MemoliB Guida

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