Hemodialysis with cuprophane membrane modulates interleukin-2 receptor expression

Kidney International
P M ZaouiR M Hakim


Chronic dialysis patients have several indices of immune deficiency. We examined the hypothesis that the biocompatibility of dialysis membranes may influence the ability of lymphocytes to express interleukin-2 (IL-2) receptors on their surface, a key event in cellular immune response. We investigated the potential role of the dialysis membrane in eight chronic hemodialysis patients. The study design was a cross-over study using cuprophane and polymethylmethacrylate (PMMA) membranes. Chronic dialysis with new cuprophane membrane leads to an increase in baseline expression of the two subunits of IL-2 receptors. IL2R alpha (p55, CD25) and IL-2R beta (p70), in peripheral blood mononuclear cell (PBMC). However, Phytohemagglutinin (PHA) stimulation of PBMC harvested after two weeks of dialysis with cuprophane membrane showed a markedly decreased expression of high affinity IL-2 receptors. These findings are reversed when patients were dialyzed with a PMMA membrane which is also associated with minimal complement activation. The increased expression of IL-2 receptor subunits are reproduced in vitro by direct contact of PBMC with cuprophane membrane and by the addition of the anaphylatoxin C5a. This study confirms the participation of ...Continue Reading


Oct 1, 1989·The Journal of Experimental Medicine·H YagitaK Okumura
Feb 1, 1989·Kidney International·D RoccatelloA Amore
Mar 1, 1989·Kidney International·F P SchenaL Aventaggiato
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L ChatenoudJ F Delfraissy
Jan 1, 1987·The Journal of Experimental Medicine·K TeshigawaraK A Smith
Jun 1, 1986·Kidney International·P KurzK H Meyer zum Büschenfelde
Apr 1, 1985·The American Journal of Medicine·R M Hakim, A I Schafer
Aug 1, 1984·Kidney International·R M HakimJ M Lazarus

❮ Previous
Next ❯


Jun 25, 1998·Journal of Biomedical Materials Research·I M KhouwM J van Luyn
Apr 17, 2004·Kidney International·Carmelo LibettaAntonio Dal Canton
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M Lazarus, W F Owen
Sep 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H RabbG Ramirez
Sep 1, 1993·Kidney International·R M Hakim
Apr 1, 1993·Kidney International·B Descamps-LatschaJ Zingraff
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I C van Riemsdijk-Van OverbeekeW Weimar
Jun 12, 2019·International Journal of Clinical Oncology·Chen XiaoHongZhang Boheng
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Jerome SampolRegis Guieu
Apr 20, 2000·Journal of the American Society of Nephrology : JASN·Alejandro Martín-MaloPedro Aljama
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·B MemoliB Guida

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.