Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs

Transfusion
O HablerK Messmer

Abstract

Intravenously administered perfluorocarbon (PFC) emulsions increase oxygen solubility in plasma. PFC might therefore temporarily replace red cells (RBCs) lost during intraoperative hemorrhage. In patients who have undergone hemodilution, the return of autologous blood may be delayed by the administration of PFC, and autologous RBCs may be saved for transfusion after surgical bleeding is stopped and PFC is cleared by the reticuloendothelial system. In 22 anesthetized, hemodiluted dogs (hemoglobin [Hb] 7 g/dL) breathing 100-percent O2, an intraoperative volume-compensated blood loss was simulated. The efficacy of three therapeutic regimens in maintaining tissue oxygenation was compared: 1) RBC group (n = 7): maintenance of a Hb > 7 g per dL by transfusion of autologous RBCs; 2) PFC group (n = 7): bolus application of a second-generation PFC emulsion (60% wt/vol perflubron) and further acute normovolemic hemodilution (ANH) to a Hb of 3 g per dL; and 3) control group (n = 7): further ANH alone to a Hb of 3 g per dL. Systemic and myocardial oxygenation status and tissue oxygenation were assessed. Autologous RBCs transfused to maintain a Hb of 7 g per dL preserved hemodynamics and tissue oxygenation during blood loss. In the PFC and ...Continue Reading

Citations

Jul 16, 2005·Der Anaesthesist·O HablerB Zwissler
Apr 13, 2007·Der Urologe. Ausg. A·O HablerB Zwissler
Jun 6, 2000·Advanced Drug Delivery Reviews·D R Spahn
Jun 6, 2000·Advanced Drug Delivery Reviews·O P Habler, K F Messmer
Aug 15, 1998·Vox Sanguinis·N S Faithfull, J G Weers
Mar 6, 2003·Vox Sanguinis·Donat R Spahn
Aug 24, 2004·Artificial Organs·Hae Won Kim, A Gerson Greenburg
Aug 12, 2010·Artificial Organs·Camila Irene Castro, Juan Carlos Briceno
Jul 21, 2004·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·G KemmingE Thein
Dec 23, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A PapeO Habler
May 2, 2012·Critical Care : the Official Journal of the Critical Care Forum·Andreas PapeOliver Habler
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·D R Spahn
Jul 22, 2008·Critical Care : the Official Journal of the Critical Care Forum·Martin K AngeleIrshad H Chaudry
Oct 24, 2006·Anesthesia and Analgesia·Kenji YoshitaniG Burkhard Mackensen
May 27, 2005·Neurosurgical Focus·M Ross BullockGraham M Teasdale
Jan 10, 2014·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A PapeO Habler
Oct 3, 2006·Current Opinion in Anaesthesiology·K F Waschke, T Frietsch
Dec 3, 2002·Anesthesiology·Donat R SpahnUNKNOWN European Perflubron Emulsion in Non-Cardiac Surgery Study Group
Jan 19, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Jasper van BommelCan Ince
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Caveh Madjdpour, Donat R Spahn
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Andreas Pape, Oliver Habler
May 13, 2005·Clinical Physiology and Functional Imaging·Jens MeierOliver Habler
Jul 5, 2006·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Raul C Verdin-VasquezJorge Barroso-Aranda
Jun 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Amy G TsaiMarcos Intaglietta

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