Hemodynamic alterations in vertebrobasilar large artery disease assessed by arterial spin-labeling MR imaging.

AJNR. American Journal of Neuroradiology
Bradley J MacIntoshP M Rothwell

Abstract

VB artery stenosis is associated with a high risk of recurrent ischemic events, and knowledge about the hemodynamic relevance of VB stenosis is important for clinical decision making. In this study, multiple inflow pulsed ASL MR imaging was assessed for its ability to measure CBF and ATT in patients with VB disease. ASL was performed on a 3T MR imaging scanner in 41 participants. Twenty-one patients had a history of ischemic events in the VB circulation (14 men, 7 women, age 66 ± 11 years). Clinical data and CE-MRA were used to classify VB disease severity. Twenty age-matched adults were controls. Group and within-VB analyses were performed. Mean CBF and ATT values in the ROIs were adjusted by excluding voxels that did not produce a reliable ASL estimate. CBF was reduced (P < .003) in patients compared with controls, which was significant after excluding voxels with a poor fit. Differences in ATT between patients and controls were not significant after voxel correction. There was a strong correlation between CBF and ATT among patients. Finally, ATT was significantly correlated with VB disease severity (P = .026). Multiple inflow ASL distinguished patients with VB disease from age matched-controls. VB disease rating was associat...Continue Reading

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Citations

Feb 5, 2013·Current Treatment Options in Cardiovascular Medicine·Aaron StaymanRishi Gupta
Aug 8, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thomas W OkellPeter Jezzard
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Dec 28, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Joseph G WoodsThomas W Okell
Jun 18, 2017·AJNR. American Journal of Neuroradiology·A D RobertsonB J MacIntosh
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Apr 7, 2016·Topics in Magnetic Resonance Imaging : TMRI·Reinoud P H BokkersJ Hendrikse

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