PMID: 6160357Jan 1, 1981Paper

Hemodynamic and arrhythmogenic effects of aconitine applied to the left atria of anesthetized cats. Effects of amiodarone and atropine

Journal of Cardiovascular Pharmacology
E Winslow

Abstract

The arrhythmogenic and hemodynamic effects of 0.04% aconitine solution applied locally to the left atria of cats and the effects of amiodarone (10 mg/kg) and atropine (0.2 mg/kg) on the responses to aconitine were investigated. Cats were anesthetized with sodium pentobarbital. The left atrial and limb lead electrocardiograms and the arterial pressure were recorded. Cardiac output was determined with the thermo dilution technique. Aconitine nitrate induced dysrhythmias lasting for a mean of 111 min. Atrial fibrillation occurred in 47% of the animals. A long-lasting (at least 3 hr) cardiodepressant action was seen in response to aconitine. Pretreatment with atropine largely prevented the hemodynamic effects of aconitine and prevented fibrillation. However, mean maximum atrial rates recorded during successive 5 min intervals were similar in control and atropine-treated animals. Amiodarone suppressed dysrhythmias in both atropine-treated and nontreated animals at a dose which exerted only minimal cardiodepression. The method described for evaluating potential activity against supraventricular dysrhythmias in the cat is relatively simple, reproducible, and suitable for statistical analyses. Aconitine appears to exert a long-lasting ...Continue Reading

Citations

Nov 1, 1991·Journal of Clinical Pharmacology·M D Freedman, J C Somberg
Jun 1, 1993·Australian and New Zealand Journal of Medicine·T Y ChanJ A Critchley
Feb 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·P Honerjäger, A Meissner
Feb 22, 2011·Pharmacology & Therapeutics·A J WorkmanA C Rankin
Apr 7, 2005·Fundamental & Clinical Pharmacology·Marcos Adriano Lessa, Eduardo Tibiriçá
Mar 1, 1989·Progress in Cardiovascular Diseases·H A Kopelman, L N Horowitz
Jul 21, 2009·Journal of Pharmacological and Toxicological Methods·Liang GuoHeather Guthrie
Feb 19, 1987·The New England Journal of Medicine·J W Mason
Dec 1, 1994·Anaesthesia and Intensive Care·A J FitzpatrickH Wolfenden
Jun 27, 2008·European Journal of Medicinal Chemistry·Abd El-Galil E AmrBakr F Abdel-Wahab

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.