PMID: 2787130Jul 1, 1989

Hemodynamic and cardiodynamic effects of propofol and etomidate: negative inotropic properties of propofol

Anesthesia and Analgesia
T BrüsselP Lawin

Abstract

The hemodynamic effects of an induction dose of propofol, 2.5 mg/kg, or etomidate, 0.3 mg/kg, were studied in eight dogs. In addition, cardiodynamic changes were measured using a left ventricular catheter and needle force probes. Propofol was associated with significant decreases in systolic (19.9%) and diastolic (25.3%) arterial pressures associated with a 17.3% decrease in cardiac output (CO) and a 11.6% reduction in systemic vascular resistance (SVR) without change in pulmonary capillary wedge pressure (PCWP). These changes were most pronounced 1 min after the injection of propofol. At 5 and 10 min after the administration of propofol, heart rate (HR) decreased significantly. Minimal changes in hemodynamics were observed with etomidate. Propofol lowered systolic left ventricular pressure (LVPsys) by 17.6%. Signals generated by the force probes in the left ventricular myocardium showed a significant reduction (16.3%) in left ventricular force (LVF) and a decrease in early systolic rates of increase in force (dF/dt max) by 23.5% associated with propofol. In the presence of an unchanged preload, an unchanged HR, and a decreased SVR, the reduction in CO suggests that propofol has a negative inotropic effect. This negative inotro...Continue Reading

Citations

Nov 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y KamijoK Arakawa
Jan 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S E BeloC D Mazer
Aug 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N R Searle, P Sahab
Dec 23, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K YamamotoT Kobayashi
Sep 28, 2004·Der Anaesthesist·J Motsch, J Roggenbach
Mar 6, 2009·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Khyati PandyaRanjan K Thakur
Mar 1, 1997·The Journal of Emergency Medicine·J M Bergen, D C Smith
Jan 25, 2000·The Journal of Emergency Medicine·D C SmithR Kirschner
Oct 20, 1999·Journal of Clinical Anesthesia·L M StrauserJoseph D Tobias
Mar 1, 2000·Acta Anaesthesiologica Scandinavica·F MarinangeliG Varrassi
Feb 13, 2001·British Journal of Pharmacology·J van KlarenboschJ J de Lange
Aug 2, 2000·Critical Care Medicine·P Van der LindenJ L Vincent
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph D Tobias
Dec 19, 2008·American Journal of Therapeutics·Jamil DarroujRohit Arora
Nov 10, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph D Tobias
Aug 1, 1991·Acta Anaesthesiologica Scandinavica·A BarakaA Bijjani
Apr 1, 1994·Acta Anaesthesiologica Scandinavica·C MartinF Gouin
Nov 1, 1990·Clinical and Experimental Pharmacology & Physiology·A F Van LeeuwenJ Ludbrook
Jan 1, 1996·British Journal of Pharmacology·Y T Xuan, P S Glass
Nov 3, 2012·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Daniel ScherzerJoseph D Tobias
Nov 21, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·A Mezzour, J-J Lehot
Aug 23, 2012·Best Practice & Research. Clinical Anaesthesiology·Markus FeussnerJoerg Ender
Oct 6, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Joseph D Tobias, Pierantonio Russo
May 27, 2003·British Journal of Anaesthesia·G N SchmidtP Bischoff

Related Concepts

Anesthetic Effect
Canis familiaris
Radenarkon
Hemodynamics
Intravenous Injections
Myocardial Contraction
Phenols
Propofol Rovi

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.