PMID: 6413136Oct 1, 1983Paper

Hemodynamic and clinical response to three-day infusion of sulmazol (AR-L 115 BS) in severe congestive heart failure

Chest
M RenardR Bernard

Abstract

Sulmazol (AR-L 115 BS) is a new positively inotropic drug with arterial and venous vasodilating properties. We studied the effects of sulmazol (three-day infusion) on clinical tolerance, hemodynamics, and blood gas levels in ten patients with severe chronic heart failure. The hemodynamic monitoring included a Swan-Ganz catheter in the pulmonary artery and a radial catheter. Blood gas levels were determined on samples of arterial and mixed venous blood. After 24 hours of infusion, there was a significant increase in cardiac index (2 to 2.5 L/min/sq m; p less than 0.005) and a significant decrease in pulmonary wedge pressure (28 to 19 mm Hg; p less than 0.001) and in right atrial pressure (7 to 4 mm Hg; p less than 0.001) without significant changes in heart rate and systolic blood pressure. These beneficial effects lasted during the three days of infusion. Oxygen delivery was significantly increased (350 to 443 ml/min/sq m; p less than 0.005) without significant change in arterial oxygen tension. The side effects included nausea, vomiting, anorexia, and mild thrombocytopenia. We conclude that sulmazol is a potent drug which may improve severely deteriorated left and right ventricular function in patients with chronic refractory ...Continue Reading

References

Aug 4, 1977·The New England Journal of Medicine·J N Cohn, J A Franciosa
Jan 1, 1977·Progress in Cardiovascular Diseases·K Chatterjee, W W Parmley
Jul 7, 1977·The New England Journal of Medicine·J N Cohn, J A Franciosa
Nov 1, 1979·The American Journal of Cardiology·C E DeschC V Leier
Dec 21, 1978·The New England Journal of Medicine·J R BenottiA A Alousi
Jul 29, 1976·The New England Journal of Medicine·W R Bell
Jun 19, 1980·The New England Journal of Medicine·V J DzauN K Hollenberg
Dec 1, 1980·Archives of Internal Medicine·D T MasonE A Amsterdam
Jul 1, 1982·Progress in Cardiovascular Diseases·H S RibnerJ Askenazi
Feb 1, 1980·British Heart Journal·P D BourdillonG C Sutton
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Mar 1, 1981·The American Journal of Cardiology·P C Kirlin, B Pitt

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Citations

Jan 1, 1992·Drug Metabolism Reviews·S Garattini
Jun 4, 1992·The American Journal of Cardiology·C V Leier
Aug 1, 1996·Current Problems in Cardiology·C V Leier
Jun 18, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Shiro IshiharaAlexandre Mebazaa
Jan 1, 1989·Basic Research in Cardiology·K Chatterjee
Sep 1, 1986·Medical Toxicology·M W Webster, D N Sharpe

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