Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm.

Neurologia Medico-chirurgica
Hiroharu KataokaSusumu Miyamoto

Abstract

Hemodynamic stress and chronic inflammation are closely associated with the pathogenesis of intracranial aneurysms (IAs). However, the hemodynamic and biological mechanisms triggering IA formation remain to be elucidated. To clarify them, computational fluid dynamics (CFD) and histopathological analyses in the early phase of IA development using an experimentally induced IA model in rats were conducted. Histological changes in the early phase of IA development were observed under a scanning electron microscope (SEM) and a transmission electron microscope (TEM). Using data from 7-T magnetic resonance angiography (7T-MRA), CFD analyses were performed to determine wall shear stress (WSS) and wall pressure (WP) at the prospective site of IA. A bump-like protrusion named an "intimal pad" was located in the anterior cerebral artery (ACA) immediately distal to the apex of the bifurcation. TEM showed the degeneration of the internal elastic lamina (IEL) and longitudinally elongated smooth muscle cells (SMCs) that switched from the contractile to the proliferative phenotype and penetrated between two divided layers of the degenerated IEL in the prospective site of the IA. However, no inflammatory cells were observed. CFD analyses showed...Continue Reading

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Dec 18, 2018·Neurologia Medico-chirurgica·Haruka MiyataTomohiro Aoki

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Citations

Jan 28, 2021·Surgical Neurology International·Mitsuhiro AnanMinoru Fujiki
Sep 2, 2021·Chinese Neurosurgical Journal·Haishuang TangQiao Zuo

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Methods Mentioned

BETA
electron microscopy
dissection

Software Mentioned

SPSS
3D Slicer
Tetra
SCRYU
Rhinoceros

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