Hemodynamic and inflammatory responses following transumbilical and transthoracic lung wedge resection in a live canine model

International Journal of Surgery
Hung-Yi LuHui-Ping Liu

Abstract

Single-port transumbilical surgery is a well-established platform for minimally invasive abdominal surgery. The aim of this study was to compare the hemodynamics and inflammatory response of a novel transumbilical technique with that of a conventional transthoracic technique in thoracic exploration and lung resection in a canine model. Sixteen dogs were randomly assigned to undergo transumbilical thoracoscopy (n = 8) or standard thoracoscopy (n = 8). Animals in the umbilical group received lung resection via a 3-cm transumbilical incision in combination with a 2.5-cm transdiaphragmatic incision. Animals in the standard thoracoscopy group underwent lung resection via a 3-cm thoracic incision. Hemodynamic parameters (e.g., mean arterial pressure, heart rate, cardiac index, systemic vascular resistance, and global end-diastolic volume index) and inflammatory parameters (e.g., neutrophil count, neutrophil 2',7' -dichlorohydrofluorescein [DCFH] expression, monocyte count, monocyte inducible nitric oxide synthase expression, total lymphocyte count, CD4+ and CD8+ lymphocyte counts, the CD4+/CD8+ratio, plasma Creactive protein level, interleukin-6 level) were evaluated before surgery, during the operation, and on postoperative days 1, ...Continue Reading

References

Dec 22, 1999·The European Respiratory Journal·T S HaugenT Lyberg
Aug 18, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S R CraigW S Walker
Nov 23, 2006·Archives of Surgery·Niamh Ni Choileain, H Paul Redmond
Jul 2, 2009·Journal of Endourology·Jens-Uwe StolzenburgEvangelos N Liatsikos
Aug 24, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Farid FroghiParaskevas Paraskeva
Apr 12, 2013·Surgical Innovation·Yi-Cheng WuHui-Ping Liu

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Citations

Jul 9, 2020·Acta Cirúrgica Brasileira·Monica Carolina Nery WittmaackPaola Castro Moraes

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