PMID: 9182081Jan 1, 1997Paper

Hemodynamic and neurohormonal effects of flosequinan in patients with heart failure

Fundamental & Clinical Pharmacology
R IsnardM Komajda

Abstract

In a double-blind, placebo-controlled study, the central and peripheral hemodynamic effects of 100 mg oral flosequinan and the impact of this drug on neurohormonal activation were noninvasively evaluated in 18 patients with congestive heart failure, after the first administration and after 10 days of treatment. No significant hemodynamic and neurohormonal changes were observed after acute administration. After 10 days, flosequinan produced central and peripheral hemodynamic improvement characterized by an increase in left ventricular circumferential fiber shortening velocity (+12%), a decrease in total systemic resistance (-36%), and an increase in leg blood flow (+37%). No significant changes were observed in heart rate and arterial pressure in patients receiving flosequinan, though a slight increase in heart rate (+17%) was recorded. Despite these favorable hemodynamic effects, flosequinan significantly increased plasma norepinephrine (+38%) and plasma renin activity (+13%) after 10 days of treatment. Thus, the beneficial central and peripheral hemodynamic effects of flosequinan are accompanied by activation of the sympathetic and reninangiotensin systems. This might be related to the unfavorable effects of the drug on surviv...Continue Reading

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Citations

Sep 11, 1998·Journal of Cardiovascular Pharmacology·M YanoM Matsuzaki
Jan 31, 2003·The Journal of Biological Chemistry·Alexander HeissWilli Jahnen-Dechent
Mar 17, 2021·Chemical Reviews·Jianlin HanVadim A Soloshonok
Mar 16, 2002·The Annals of Pharmacotherapy·Craig R LeeJ Herbert Patterson

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