Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach

Journal of Biomechanics
Filippo PiattiDanny Bluestein

Abstract

Surgical valve replacement in patients with severe calcific aortic valve disease using either bioprosthetic or mechanical heart valves is still limited by structural valve deterioration for the former and thrombosis risk mandating anticoagulant therapy for the latter. Prosthetic polymeric heart valves have the potential to overcome the inherent material and design limitations of these valves, but their development is still ongoing. The aim of this study was to characterize the hemodynamics and thrombogenic potential of the Polynova polymeric trileaflet valve prototype using a fluid-structure interaction (FSI) approach. The FSI model replicated experimental conditions of the valve as tested in a left heart simulator. Hemodynamic parameters (transvalvular pressure gradient, flow rate, maximum velocity, and effective orifice area) were compared to assess the validity of the FSI model. The thrombogenic footprint of the polymeric valve was evaluated using a Lagrangian approach to calculate the stress accumulation (SA) values along multiple platelet trajectories and their statistical distribution. In the commissural regions, platelets were exposed to the highest SA values because of highest stress levels combined with local reverse f...Continue Reading

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Citations

Oct 16, 2018·Expert Review of Medical Devices·Oren M RotmanDanny Bluestein
Mar 8, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Oren M RotmanDanny Bluestein
Apr 2, 2016·The International Journal of Artificial Organs·Filippo ConsoloAlberto Redaelli
Jan 13, 2018·Cardiovascular Engineering and Technology·Saleh Hassanzadeh GharaieYosry Morsi
Nov 16, 2016·Cardiovascular Engineering and Technology·Wenbin MaoWei Sun
Jan 6, 2018·Biomechanics and Modeling in Mechanobiology·Rodrigo Méndez RojanoFranck Nicoud
Nov 11, 2019·Medical & Biological Engineering & Computing·Bin GaoYu Chang
Jan 1, 2021·Journal of the Mechanical Behavior of Biomedical Materials·A CavalloG Soldani
Jun 27, 2021·Cardiovascular Engineering and Technology·Hao WangZhaoming He
Oct 31, 2021·Computers in Biology and Medicine·Armin AbdehkakhaHui Meng

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