Hemodynamic assessment of splenomegaly in beta-thalassemia patients undergoing splenectomy

Annals of Hematology
Athanasios AessoposEfstathios Papalambros

Abstract

Splenomegaly is a common finding in beta-thalassemia; however, its hemodynamic features and its potential correlations with high output state and hepatic disorders, both also frequent in thalassemia, have not yet been assessed in these patients. Eight beta-thalassemia patients with the indication for splenectomy and no symptoms or signs of heart disease, aged 25.6+/-5.5 years, were studied. Preoperative assessment included hematological profile, liver biology, hepatitis virus serology, and echocardiography. During splenectomy, splenic artery blood flow and splenic vein pressure were directly measured and liver biopsies were taken. Preoperative echocardiographic data were compared with those of 34 healthy controls. The preoperative cardiac index was significantly elevated in patients (4.8+/-1.3 vs 3.4+/-1.1 l/min per m2 in controls, p<0.001). Splenic blood flow, although increased, was not particularly high, being 285+/-56 ml/min or 0.13+/-0.04 ml/min per g of splenic mass, representing 4.1+/-0.9% of total cardiac output (CO). Splenic vein pressure was considerably elevated (29.7+/-5.5 cmH2O). Hepatic fibrosis, iron deposition, and extramedullary foci were found in all eight biopsies. Serology was positive in five of eight cases...Continue Reading

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Citations

Nov 23, 2006·European Journal of Clinical Pharmacology·Nuntiya SomparnVeerapol Kukongviriyapan
Feb 16, 2005·Annals of Hematology·Athanasios AessoposEfstathios Papalambros
Jan 17, 2014·The Lancet. Respiratory Medicine·Anastasia AnthiApostolos Armaganidis
Oct 30, 2010·Clinical Pharmacokinetics·Lie Michael George LimentaNoppawan Phumala Morales
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Athanasios Aessopos, Vasilios Berdoukas
May 1, 2007·Transfusion·Athanassios AessoposJohn Meletis
Jul 7, 2011·Pediatric Hematology and Oncology·Khadijeh Arjmandi RafsanjaniR Isa Tafreshi
Nov 26, 2010·JRSM Short Reports·Kerry A Layne, Ian Starke
Dec 17, 2009·Hemoglobin·A AessoposD Farmakis
Jan 1, 2011·Clinical Pharmacokinetics·Lie Michael George LimentaNoppawan Phumala Morales

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