Hemodynamic assessment of the development of portal-systemic collaterals in portal hypertensive rats.

Digestive Diseases and Sciences
Che-Chang ChanHan-Chieh Lin

Abstract

Portal hypertension induced the formation of portal-systemic collaterals. Revealing the developmental change of portal-systemic collaterals is important for future therapy. We observed the evolution of an accessible shunting vessel, the spleno-renal shunt (SRS), in rats after induction of portal hypertension by partial portal vein ligation (PVL). The hemodynamic and histological assessments of SRS were performed by transit time ultrasound and immunohistochemical studies. The portal pressure of PVL rats surged to 16.5 ± 1.1 mmHg on day 1 after ligation surgery and was maintained at a significantly higher level (13.0 ± 0.4 mmHg) to day 14 when compared to sham rats (p < 0.05). The size or flow of SRS in PVL rats did not change immediately after portal pressure surge. Instead, they increased rapidly on day 4, peaked on day 7, and stabilized thereafter. The size and flow were greater and the resistance of SRS was lower in PVL rats after day 7 (p < 0.05). The anti-Ki67 immunohistochemical study demonstrated positive staining of endothelium in SRS and negative in portal vein or aorta of PVL rats. In addition, the endothelial cells of SRS were stained positive for CD31 and KLF5. We concluded that the pressure-induced opening of pre-ex...Continue Reading

References

Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K TanoueK Sugimachi
Dec 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P PizcuetaJ Rodés
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J Kroeger, R J Groszmann
May 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Garcia-TsaoM Glickman
Jan 1, 1974·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J F Halvorsen, A O Myking
Apr 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·S I MyersA Castaneda
Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P CalèsR Trouvé
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C C ChanS D Lee
Jun 30, 2005·Journal of the Chinese Medical Association : JCMA·Ching-Chih ChangShou-Dong Lee
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·R NagaiI Manabe
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mercedes FernandezJaime Bosch
May 13, 2008·Gastroenterology·Arun J SanyalVincente Arroyo
May 27, 2009·Journal of the Chinese Medical Association : JCMA·Che-Chang Chan
Jul 7, 2009·The Medical Clinics of North America·David A Sass, Kapil B Chopra

❮ Previous
Next ❯

Citations

Apr 8, 2015·World Journal of Hepatology·Gülsüm Özlem Elpek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.