PMID: 9524946Apr 3, 1998Paper

Hemodynamic changes during administration of drugs for mitral regurgitation in dogs

The Journal of Veterinary Medical Science
Y Uehara, M Takahashi

Abstract

Each of 5 drugs, i.e., 4 different vasodilator drugs (captopril, enalapril, hydralazine and prazosin) and a cardiotonic drug (digoxin), was administered to dogs with mitral regurgitation (MR) for 1-72 days in order to quantitatively evaluate the influence of therapeutic agents on blood flow in heart disease. Hemodynamic changes were assessed before and after administration of each drug by determining mitral regurgitant jet mapping area (MRMA) and aortic forward flow mapping area (AFMA), which were displayed by the color Doppler method, and the ratio of MRMA to AFMA (MRMA/AFMA) as parameters. When the four vasodilator drugs were used appropriately, MRMA and MRMA/AFMA decreased in all cases, compared with the values before the administration. These two parameters showed dose-dependent changes after administration of captopril, enalapril and hydralazine. When the cardiotonic drug was used. MRMA and MRMA/AFMA increased in 4 of 5 cases. The MRMA/AFMA values were slightly more reproducible than the MRMA values, whereas the AFMA values showed no constant tendency when any vasodilator drug or the cardiotonic drug was used. These results suggest that the efficacy of cardiotonic and vasodilator drugs in MR can be quantitatively evaluated...Continue Reading

References

Apr 1, 1990·Nihon juigaku zasshi. The Japanese journal of veterinary science·I KanemotoY Shimizu
Mar 1, 1993·Journal of Veterinary Pharmacology and Therapeutics·M D KittlesonY E Mekhamer
Mar 1, 1996·The Journal of Veterinary Medical Science·Y Uehara, M Takahashi
Jan 1, 1958·The American Journal of Physiology·M D Cotten, P E Stopp

❮ Previous
Next ❯

Citations

Mar 6, 2012·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Clarke E Atkins, Jens Häggström
Sep 22, 2009·The Journal of Small Animal Practice·J HäggströmM Borgarelli
Jan 5, 2002·The Journal of Veterinary Medical Science·Y NagashimaY Yamane
Mar 31, 1999·The Veterinary Clinics of North America. Small Animal Practice·J D Bonagura, M W Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.