PMID: 6973939Sep 1, 1981Paper

Hemodynamic changes during fentanyl--oxygen anesthesia for aortocoronary bypass operation

Anesthesiology
J L WallerJ M Craver

Abstract

Fentanyl in doses of 50-60 microgram/kg has been reported to produce anesthesia with remarkable hemodynamic stability in patients with coronary artery disease (CAD). Because the authors had observed hypertension and tachycardia in response to noxious stimulation during aortocoronary bypass (ACB) operations in patients so anesthetized, they studied the hemodynamic changes and anesthetic conditions produced by fentanyl/O2/relaxant anesthesia in patients undergoing elective ACB. Twelve patients with left ventricular (LV) ejection fractions greater than 0.4 were maintained on propranolol until 10 hours before operation and were premedicated with fentanyl, diazepam, and scopolamine. Cannulae were inserted before the study commenced for measurement of intravascular pressures, arterial blood gases, and thermodilution cardiac output. The patients breathed 100 per cent oxygen throughout the study. Controlled ventilation aided by succinylcholine to reduce truncal rigidity maintained PaCO2 at 30-45 torr. Measurements were made after each of the following: breathing oxygen (control), 10 microgram/kg fentanyl, 50 microgram/kg fentanyl, and 0.1 mg/kg pancuronium, tracheal intubation, skin incision, and sternotomy. Fentanyl alone produced no ...Continue Reading

Citations

Sep 1, 1986·Canadian Anaesthetists' Society Journal·F A BurrowsD J Bohn
Nov 1, 1994·Acta Anaesthesiologica Scandinavica·R StensethS E Gisvold
Nov 1, 1986·Acta Anaesthesiologica Scandinavica·W Hess, C Meyer
Feb 1, 1985·Acta Anaesthesiologica Scandinavica·M HynynenA M Lehtinen
Sep 1, 1988·Journal of Anesthesia·A WatanabeM Aoki
Jul 1, 1986·Canadian Anaesthetists' Society Journal·A J BoultonR W Yip
Nov 1, 1984·Canadian Anaesthetists' Society Journal·E A MoffitC E Kinley
Jan 1, 1983·Canadian Anaesthetists' Society Journal·L L Priano
Jul 1, 1984·Canadian Anaesthetists' Society Journal·T H Stanley, S de Lange
Oct 1, 1996·Acta Anaesthesiologica Scandinavica·T Heier, P A Steen
Nov 1, 1983·Anaesthesia and Intensive Care·P J Maddern
Dec 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R J KowalewskiB Bharadwaj
Dec 1, 1984·Acta Anaesthesiologica Scandinavica·H HeikkiläV Laaksonen
Mar 22, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Glenn BurnsHenry A Spiller
Mar 23, 2018·Expert Review of Cardiovascular Therapy·Noor Ul-Ain BalochOmar Rahman
Sep 10, 2019·British Journal of Pharmacology·Rob HillGraeme Henderson
May 1, 1986·Canadian Anaesthetists' Society Journal·D H SethnaF G Estafanous
May 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D R MillerR D Weisel
Mar 23, 2002·International Anesthesiology Clinics·Samir Patel
Sep 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R Hall
Jan 1, 1997·European Journal of Clinical Pharmacology·M BorensteinT B Tzeng
Jan 1, 1990·Journal of Anesthesia·T MayumiS Dohi
Sep 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S N KonstadtD M Thys
Aug 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·R J RobinsonJ A Magovern

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