Hemodynamic characteristics and predictors of pulmonary hypertension in patients with sickle cell disease.

The American Journal of Cardiology
Melissa CaugheyKenneth I Ataga

Abstract

Pulmonary hypertension is a common co-morbidity of sickle cell disease with an associated increased mortality risk, but its etiology is not well-understood. To evaluate the hemodynamic characteristics, clinical predictors, and cardiovascular manifestations of elevated pulmonary arterial pressure in this population, we performed noninvasive hemodynamic assessments of 135 patients with sickle cell disease using Doppler echocardiography. A diagnosis of pulmonary hypertension was determined by gender-, age-, and body mass index-specific normal reference ranges for tricuspid regurgitation jet velocities (TRVs). A high TRV was noted in 34 patients (25%). Pulmonary vascular resistance was elevated in only 2 (6%) of the 34 patients with suspected pulmonary hypertension but was significantly greater than in those with normal TRV. On univariate regression, the TRV correlated with age, body mass index, left atrial pressure, and right ventricular stroke volume and was negatively associated with hemoglobin and glomerular filtration rate. The left atrial pressure, right ventricular stroke volume, and hemoglobin remained independent predictors of TRV in a multivariate model. A greater TRV was also associated with larger right ventricular and ...Continue Reading

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Citations

Sep 7, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marcia M BarbosaMaria Carmo P Nunes
Feb 22, 2016·JACC. Cardiovascular Imaging·Melissa C CaugheyAlan L Hinderliter
Feb 22, 2016·JACC. Cardiovascular Imaging·Omar NissMichael D Taylor
Apr 10, 2015·British Journal of Haematology·Melissa C CaugheyAlan L Hinderliter
Aug 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Nihal BakeerPunam Malik
Sep 10, 2016·JACC. Cardiovascular Imaging·Omar NissMichael D Taylor
Sep 15, 2017·PloS One·Ogochukwu J SokunbiChristy A N Okoromah
Apr 22, 2019·European Heart Journal·Nadjib HammoudiGilles Montalescot
Mar 2, 2017·The Journal of Clinical Investigation·Gregory J KatoMark T Gladwin
Sep 15, 2020·Curēus·Harsimran KaurBilal Haider Malik
Apr 30, 2017·Pediatric Blood & Cancer·Parul RaiPunam Malik

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