Abstract
Pulmonary hypertension is a common co-morbidity of sickle cell disease with an associated increased mortality risk, but its etiology is not well-understood. To evaluate the hemodynamic characteristics, clinical predictors, and cardiovascular manifestations of elevated pulmonary arterial pressure in this population, we performed noninvasive hemodynamic assessments of 135 patients with sickle cell disease using Doppler echocardiography. A diagnosis of pulmonary hypertension was determined by gender-, age-, and body mass index-specific normal reference ranges for tricuspid regurgitation jet velocities (TRVs). A high TRV was noted in 34 patients (25%). Pulmonary vascular resistance was elevated in only 2 (6%) of the 34 patients with suspected pulmonary hypertension but was significantly greater than in those with normal TRV. On univariate regression, the TRV correlated with age, body mass index, left atrial pressure, and right ventricular stroke volume and was negatively associated with hemoglobin and glomerular filtration rate. The left atrial pressure, right ventricular stroke volume, and hemoglobin remained independent predictors of TRV in a multivariate model. A greater TRV was also associated with larger right ventricular and ...Continue Reading
References
Aug 1, 1985·Journal of the American College of Cardiology·M BergerE Goldberg
Oct 1, 1985·Journal of the American College of Cardiology·P J CurrieA J Tajik
Oct 1, 1984·Circulation·P G Yock, R L Popp
Mar 13, 1999·Annals of Internal Medicine·A S LeveyD Roth
Feb 13, 2001·European Heart Journal·J MeluzínM Soucek
Dec 6, 2001·Circulation·B M McQuillanA E Weyman
Dec 14, 2002·American Journal of Respiratory and Critical Care Medicine·Selim M ArcasoyRobert M Kotloff
Mar 26, 2003·Journal of the American College of Cardiology·Amr E AbbasSteven J Lester
May 2, 2003·Nature Medicine·Mark T GladwinAlan N Schechter
Feb 27, 2004·The New England Journal of Medicine·Mark T GladwinFrederick P Ognibene
Jun 11, 2004·The New England Journal of Medicine·Elizabeth S Klings, Harrison W Farber
Oct 27, 2004·The American Journal of Medicine·Kenneth I AtagaEugene P Orringer
May 23, 2006·Atherosclerosis·Athanasios AessoposMarkisia Karagiorga
Jun 29, 2006·British Journal of Haematology·Kenneth I AtagaEugene P Orringer
May 10, 2007·Haematologica·Athanasios AessoposDimitrios Farmakis
Aug 29, 2007·American Journal of Hematology·Laura M De CastroMarilyn J Telen
Nov 21, 2008·The New England Journal of Medicine·Mark T Gladwin, Elliott Vichinsky
Dec 25, 2008·Annals of Hematology·Athanasios AessoposMarkisia Karagiorga
Jan 24, 2009·American Journal of Respiratory and Critical Care Medicine·Micah R FisherPaul M Hassoun
May 13, 2009·Circulation·Carolyn S P LamMargaret M Redfield
Aug 25, 2009·The American Journal of Cardiology·Niti DhamCraig Sable
Sep 3, 2009·Current Heart Failure Reports·Sherif F Nagueh
Oct 30, 2010·Archives of Disease in Childhood·Rifat A ChaudrySuzanne Crowley
Mar 23, 2011·Circulation·Dimitrios Farmakis, Athanasios Aessopos
Jul 8, 2011·The New England Journal of Medicine·Florence ParentGerald Simonneau
Citations
Sep 7, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marcia M BarbosaMaria Carmo P Nunes
Feb 22, 2016·JACC. Cardiovascular Imaging·Melissa C CaugheyAlan L Hinderliter
Feb 22, 2016·JACC. Cardiovascular Imaging·Omar NissMichael D Taylor
Dec 19, 2014·Echocardiography·Newton Nunes de Lima-FilhoOrlando Campos
Apr 10, 2015·British Journal of Haematology·Melissa C CaugheyAlan L Hinderliter
Aug 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Nihal BakeerPunam Malik
Sep 10, 2016·JACC. Cardiovascular Imaging·Omar NissMichael D Taylor
Sep 15, 2017·PloS One·Ogochukwu J SokunbiChristy A N Okoromah
Apr 22, 2019·European Heart Journal·Nadjib HammoudiGilles Montalescot
Mar 2, 2017·The Journal of Clinical Investigation·Gregory J KatoMark T Gladwin
Sep 15, 2020·Curēus·Harsimran KaurBilal Haider Malik
Apr 30, 2017·Pediatric Blood & Cancer·Parul RaiPunam Malik