Hemodynamic characterization of aortic stenosis states

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Amr E Abbas, Philippe Pibarot

Abstract

Aortic stenosis (AS) has become an increasingly prevalent clinical condition, as a result of the "greying of the population", the widespread application of sophisticated diagnostic tools including non-invasive imaging and invasive techniques, and the advent of minimally invasive surgical and percutaneous valve therapies. The diagnosis of severe AS traditionally has relied on the assessment of the mean transvalvular gradient (ΔPmean ) and aortic valve area (AVA) by either echocardiography or catheterization. However, other hemodynamic variables as flow, pressure recovery, and jet eccentricity also play a major role in determining the final hemodynamic state of AS. Moreover, mismatch between ΔPmean and AVA as in low flow low gradient AS and discordance between catheterization and echocardiographic studies in grading severity of AS have increased the complexity of AS diagnosis. The present case-based treatise emphasizes a multi-modality approach to delineation of the hemodynamic pathophysiology of different AS states. KEY POINTS: Reduction in the aortic valve area, flow across the aortic valve, and direction of the aortic stenosis jet determine the pressure gradient generated across the aortic valve in patients with aortic stenosi...Continue Reading

References

Mar 1, 1980·British Heart Journal·L HatleA Tromsdal
Dec 5, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Piers C A BarkerAlbert P Rocchini
Sep 19, 2006·Lancet·Vuyisile T NkomoMaurice Enriquez-Sarano
Feb 8, 2007·Current Opinion in Cardiology·Ian G Burwash
Jan 10, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Helmut BaumgartnerUNKNOWN European Association of Echocardiography
Jan 14, 2012·Journal of the American College of Cardiology·Patrizio LancellottiLuc A Piérard
Jul 14, 2012·Journal of the American College of Cardiology·Philippe Pibarot, Jean G Dumesnil
Jan 3, 2013·Journal of Interventional Cardiology·Amr E AbbasSteven Lester
Nov 29, 2015·The Journal of Thoracic and Cardiovascular Surgery·George L ZornMichael J Reardon
Jan 18, 2017·Circulation. Cardiovascular Imaging·Fabrizio DonatiPablo Lamata
Apr 8, 2017·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Helmut BaumgartnerCatherine M Otto
Feb 7, 2018·Journal of the American College of Cardiology·Mohamed-Salah AnnabiMarie-Annick Clavel

❮ Previous
Next ❯

Citations

Aug 23, 2019·European Heart Journal Cardiovascular Imaging·Ezequiel GuzzettiMarie-Annick Clavel
Apr 28, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Kerstin PiaydaTobias Zeus
Dec 22, 2020·Frontiers in Cardiovascular Medicine·Ezequiel GuzzettiMarie-Annick Clavel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.