Hemodynamic Deterioration of Surgically Implanted Bioprosthetic Aortic Valves

Journal of the American College of Cardiology
Erwan SalaunPhilippe Pibarot

Abstract

Dysmetabolic profile has been associated with native aortic valve stenosis. However, there are limited data on the effects of an atherogenic milieu and its potential implications on the structural and hemodynamic deterioration of aortic bioprosthetic valves. This prospective longitudinal study sought to determine the predictors and impact on outcomes of hemodynamic valve deterioration (HVD) of surgically implanted aortic bioprostheses. A total of 137 patients with an aortic bioprosthesis implanted for a median time of 6.7 (interquartile range: 5.1 to 9.1) years prospectively underwent a first (baseline) assessment with complete Doppler echocardiography, quantitation of bioprosthesis leaflet calcification by multidetector computed tomography (CT), and a fasting blood sample to assess cardiometabolic risk profile. All patients underwent a second (follow-up) Doppler echocardiography examination at 3 (interquartile range: 2.9 to 3.3) years post-baseline visit. HVD was defined by an annualized change in mean transprosthetic gradient ≥3 mm Hg/year and/or worsening or transprosthetic regurgitation by ≥1/3 class. The primary endpoint was a nonhierarchical composite of death from any cause or aortic reintervention procedure (redo surgic...Continue Reading

Citations

Dec 24, 2018·Current Opinion in Cardiology·Amine MazineBobby Yanagawa
Dec 19, 2018·Current Opinion in Cardiology·Erwan SalaunPhilippe Pibarot
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Oct 10, 2020·Journal of the American College of Cardiology·Bin ZhangMarie-Annick Clavel
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