Hemodynamic effects of acute hyperoxia: systematic review and meta-analysis

Critical Care : the Official Journal of the Critical Care Forum
Bob SmitAngelique M E Spoelstra-de Man

Abstract

In clinical practice, oxygen is generally administered to patients with the intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial hyperoxia, which is associated with hemodynamic alterations. We performed a systematic review and meta-analysis of the literature to determine the effect of hyperoxia on central hemodynamics and oxygen delivery in healthy volunteers and cardiovascular-compromised patients. PubMed and EMBASE were searched up to March 2017. Studies with adult humans investigating changes in central hemodynamics or oxygen delivery induced by acute normobaric hyperoxia were included. Studies focusing on lung, retinal, or brain parameters were not included. We extracted subject and oxygen exposure characteristics, indexed and unindexed values for heart rate, stroke volume, cardiac output, mean arterial pressure (MAP), systemic vascular resistance, and oxygen delivery during normoxia and hyperoxia. For quantitative synthesis of the data, a random-effects ratio of means (RoM) model was used. We identified 33 studies with 42 datasets. Study categories included healthy volunteers (n = 22 datasets), patients with coronary artery disease (CAD; n = 6), heart failure (HF; n = 6), coronary arter...Continue Reading

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Citations

Aug 6, 2018·Journal of Cellular Physiology·Jennifer L RodgersSiva K Panguluri
Jan 18, 2019·Journal of Cellular Physiology·Jennifer L RodgersSiva K Panguluri
Nov 5, 2019·Minerva anestesiologica·Sara OttolenghiDavide Chiumello
Mar 4, 2020·Journal of Clinical Medicine·Robert P WeeninkMarkus W Hollmann
Mar 29, 2019·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint
Jul 6, 2018·International Journal of Molecular Sciences·Jochen HinkelbeinAndreas Hohn
Feb 25, 2020·Journal of the American Heart Association·Dominik P GuenschBalthasar Eberle
Aug 28, 2020·Frontiers in Physiology·Verena TretterKlaus Ulrich Klein
May 1, 2019·Journal of Cardiovascular Development and Disease·Jennifer L RodgersSiva K Panguluri
Oct 20, 2020·Journal of Intensive Care·Satoshi Suzuki
Oct 24, 2020·Irish Journal of Medical Science·Shi-Jin LvFei Zhao
Nov 12, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Tina Tomic MahecicJens Meier

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

Graphad Prism
GraphPad

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