PMID: 1209645Nov 1, 1975Paper

Hemodynamic effects of aerosol propellants. I. Cardiac depression in the dog

Toxicology
J A Simaan, D M Aviado

Abstract

The inhalation of fluorocarbons caused a depression of myocardial contractility, aortic hypotension, a decrease in cardiac output and an increase in pulmonary vascular resistance. The minimal concentrations that elicited these changes are as follows: 1% trichlorofluoromethane (FC11); 2.5% dichlorotetrafluoroethane (FC114); and 10% dichlorodifluoromethane (FC12). Inhalation of 20% octafluorocyclobutane (FC318) and difluoroethane (FC152a) did not influence these hemodynamic parameters. As in previous comparisons, the most widely used aerosol propellants are potentially cardiotoxic in the anesthetized dog.

Citations

Mar 9, 2011·Journal of Agricultural and Food Chemistry·Shih-Hao WangRobin Y-Y Chiou
Sep 1, 1994·Journal of Toxicology and Environmental Health·C A BranchJ Gayner
Nov 29, 2015·Cardiovascular Toxicology·Suwen KumarHeather S Laird-Fick
Aug 1, 1990·Stroke; a Journal of Cerebral Circulation·C A BranchK M Welch

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