Nov 1, 1975

Hemodynamic effects of aerosol propellants. II. Pulmonary circulation in the dog

Toxicology
J A Simaan, D M Aviado

Abstract

The inhalation of trichlorofluoromethane (FC11), dichlorotetrafluoroethane (FC114) and dichlorodifluoromethane (FC12) caused a reduction in mean aortic blood pressure but only FC11 and FC114 caused a reduction in mean pulmonary arterial pressure. The primary cause of the fall is a decrease in pulmonary blood flow. When blood flow to a lobe is kept constant and the adrenergic alpha receptors are blocked by injection of phentolamine, the inhalation of FC11 caused vasodilation. In the intact circulation, the vasodilation is masked by release of catecholamines which constrict the pulmonary blood vessels.

  • References1
  • Citations4

References

Mentioned in this Paper

Lung
Blood Vessel
Diastolic Blood Pressure
Catecholamines Measurement
Adrenergic alpha-Antagonists
Blood Flow
Anoxemia
Aorta
Aerosol Dose Form
AKT1S1 wt Allele

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