PMID: 6414278Sep 22, 1983Paper

Hemodynamic effects of antiarrhythmic drugs

The American Journal of Cardiology
P J Block, R A Winkle

Abstract

In order to use antiarrhythmic drugs safely, one must understand their hemodynamic effects. Quinidine and the calcium antagonists have direct cardiac effects and frequently opposing autonomically mediated or indirect cardiac effects. Lidocaine is exceptionally well tolerated, even by patients with severe left ventricular dysfunction. Phenytoin and procainamide have the potential for serious adverse effects, but are generally well tolerated at usual doses. Disopyramide causes serious depression of left ventricular function in many patients because of its direct myocardial depressant and peripheral vasoconstricting actions. Although bretylium causes an immediate increase in contractility, it can ultimately result in important hypotension. In this review the in vitro and in vivo hemodynamic effects of these and other antiarrhythmic drugs are discussed to provide information that will assist the clinician in using these drugs properly.

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Citations

Nov 1, 1990·Journal of Clinical Pharmacology·P J Podrid
Jan 1, 1984·European Journal of Clinical Pharmacology·E RivaR Urso
Dec 1, 1983·The American Journal of Cardiology·S J ConnollyR A Winkle
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May 19, 2021·Journal of Molecular and Cellular Cardiology·Pei-Chi YangColleen E Clancy

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