Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat

Critical Care Medicine
C Steinberg, D A Notterman

Abstract

To determine the pharmacologic effect of carcinine (beta-alanyl histamine), a compound that has been shown to be a positive inotrope in the isolated perfused guinea pig heart, on hemodynamics in an intact, anesthetized rat model. Prospective dose-response study. Animal research laboratory of a university medical center. Male Sprague-Dawley rats. Eight male Sprague-Dawley rats were anesthetized with ketamine and midazolam. A tracheostomy tube, and central venous and arterial catheters were inserted. An electromagnetic flow probe was placed around the ascending aorta through a right thoracotomy for measurement of cardiac output. Dosages of carcinine from 0 to 10 mg/kg were infused intravenously over 30 secs, and hemodynamic parameters were measured at baseline and at peak effect. At dosages of 3 mg/kg and 10 mg/kg, carcinine significantly reduced mean arterial blood pressure, systemic vascular resistance index, and left ventricular stroke work index. There was no carcinine-induced effect on heart rate, central venous pressure, cardiac index, or stroke index. Lower doses of carcinine had no effect on the measured variables. In this open-chest rat model, the primary pharmacologic effect of carcinine is systemic arterial vasodilatio...Continue Reading

References

Jul 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·D E FisherH Fisher
Oct 1, 1990·The Journal of Surgical Research·J C FitzpatrickL Flancbaum
Mar 1, 1990·Critical Care Medicine·D N BrotmanH Fisher

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Citations

Nov 22, 2005·PLoS Genetics·John R TrueJianyong Li

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