PMID: 3349517Jan 1, 1988Paper

Hemodynamic effects of contrast media during coronary angiography: a comparison of three nonionic agents to Hypaque-76

Catheterization and Cardiovascular Diagnosis
Z E PiaoP J Scanlon


Coronary angiography with standard ionic contrast media is associated with marked alterations in cardiac hemodynamics because of the depressant effects of the contrast media on cardiac contractility. Nonionic contrast media have been reported to produce less hemodynamic alteration than standard ionic contrast media. However, there is no information on how one nonionic media compares to another. Thus we compared the hemodynamic effects of three nonionic contrast media, Iopamidol (IOP), Iohexol (IOH), and Ioversol (IOV) to each other as well as to the standard ionic contrast media Hypaque-76 (H76). In 20 closed-chest anesthetized dogs, we recorded the maximal change in left ventricular systolic pressure (LVSP), mean aortic pressure, left ventricular diastolic pressure (LVDP), and left ventricular dp/dt during 10-cc left main coronary artery injections of H76, IOP, IOH, and IOV. The mean aortic pressure and LVSP decreased 36 +/- 17 mm Hg and 46 +/- 21 mm Hg with H76 but only 5 +/- 5 mm Hg and 6 +/- 5 mm Hg with IOP, 5 +/- 4 mm Hg and 6 +/- 6 mm Hg with IOH, and 5 +/- 4 mm Hg and 7 +/- 6 mm Hg with IOV (P less than 0.001). The LVDP increased 6 +/- 5.0 mm Hg with H76 but only 0.2 +/- 0.5 mm Hg with IOP, 0.2 +/- 0.3 mm Hg with IOH, a...Continue Reading


Sep 1, 1976·Investigative Radiology·R A Chahine, A E Raizner
Jul 1, 1975·Circulation·J B CaulfieldJ W Harthorne
Jun 2, 1966·The New England Journal of Medicine·A Benchimol, E M McNally
Jan 1, 1970·The American Journal of Cardiology·N GootmanN M Buckley
Sep 1, 1966·Investigative Radiology·F E KlosterH E Griswold
Jan 1, 1984·Catheterization and Cardiovascular Diagnosis·D K MurdockP J Scanlon
Sep 1, 1982·Investigative Radiology·T W MorrisH W Fischer
Jan 1, 1982·Catheterization and Cardiovascular Diagnosis·J W KennedyM Cohen
May 1, 1980·Investigative Radiology·K R ThomsonG T Benness
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Oct 1, 1961·The American Journal of Physiology·W G NAYLER

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Dec 1, 1990·Catheterization and Cardiovascular Diagnosis·M H HwangS H Sheu
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Mar 1, 1991·Current Problems in Diagnostic Radiology·H O Stolberg, B L McClennan
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