Hemodynamic effects of interpleural lidocaine and bupivacaine combination in anesthetized dogs with and without an open pericardium

Veterinary Surgery : VS
Fabrice BernardEric Monnet

Abstract

To identify dysrhythmias and hemodynamic changes after lidocaine and bupivacaine infusion into the interpleural space with an open pericardium. Experimental study. Six adult dogs. Systemic arterial pressure and electrocardiogram were recorded. A 7.5 Fr Swan-Ganz catheter was advanced to the level of the main pulmonary artery to record pulmonary arterial pressure. Cardiac output was measured by a thermodilution technique. A pericardial window (PW) was performed in 3 dogs using thoracoscopy. Hemodynamic variables were recorded before and 15 minutes after injection of lidocaine (1.5 mg/kg) and bupivacaine (1.5 mg/kg) into the pleural space in the control group and in the pericardial space for the PW group. A randomized-block ANOVA for repeated measures was used to evaluate the effect of local anesthetic administration on hemodynamic and electrophysiologic variables in dogs with a pericardectomy. Each dog maintained sinus rhythm. Infusion of local anesthetic induced a significant increase in right ventricular diastolic pressure (P = .002) and a significant decrease in stroke volume (P = .047) in both groups; however, the effects were not significantly different between groups. Infusion of lidocaine and bupivacaine, either intrapleu...Continue Reading

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Citations

Jan 30, 2008·Bulletin of Experimental Biology and Medicine·N A Mangusheva, L L Katalymov
Oct 23, 2009·Veterinary Anaesthesia and Analgesia·Amanda L AbelsonCheryl Blaze
Sep 28, 2015·The Veterinary Clinics of North America. Small Animal Practice·MaryAnn Radlinsky
Apr 8, 2011·Asian Cardiovascular & Thoracic Annals·Mojtaba MansouriAtefeh Gholami Ahangaran
Jun 5, 2020·Circulation. Arrhythmia and Electrophysiology·Sharan Prakash SharmaDhanunjaya Lakkireddy

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