Abstract
Using an echo-Doppler method (Quantascope), the hemodynamic profile of the calcium channel antagonist elgodipine (64 micrograms/kg, i.v.) was investigated in 22 patients with angina pectoris at rest and during exercise. A placebo control was used. At rest, elgodipine significantly decreased systemic vascular resistance as well as systolic and diastolic blood pressure, while increasing cardiac output and stroke volume. During supine bicycle exercise the constant workload, elgodipine significantly increased cardiac output and stroke volume, and decrease the rate-pressure-product (double product); the exercise systolic blood pressure was decreased without change in the diastolic component. Elgodipine significantly reduced the incidence and severity (self-rated pain score) of exercise-induced anginal systems. Heart rate was not affected by elgodipine, either at rest or during exercise. In particular, no negative inotropy could be inferred from the echo-Doppler data. In the elgodipine plasma concentration profile (HPLC), three phases of elimination with half-life times of less than 1 hour, between 3 and 7 hours, and between 10 and 24 hours may be distinguished, indicating a "shallow" and a "deep" compartment. The hemodynamic data in...Continue Reading
References
Jan 1, 1979·Ultrasonic Imaging·C F Hottinger, J D Meindl
Jan 1, 1979·Medical & Biological Engineering & Computing·M Ramsey
May 1, 1992·The American Journal of Cardiology·H SuryapranataP W Serruys
Jun 1, 1992·Clinical Pharmacokinetics·J G Kelly, K O'Malley
Nov 1, 1990·Journal of Cardiovascular Pharmacology·W BurgerG Kober
Jun 1, 1990·British Journal of Clinical Pharmacology·B SilkeS H Taylor
Apr 1, 1990·British Journal of Clinical Pharmacology·B SilkeS H Taylor
Apr 1, 1990·Cardiovascular Drugs and Therapy·B SilkeS H Taylor
Jan 1, 1989·Ultrasound in Medicine & Biology·J M EvansP N Wells
Jan 1, 1989·Ultrasound in Medicine & Biology·J M EvansP N Wells
Oct 17, 1989·The American Journal of Cardiology·B SilkeS H Taylor
Jan 1, 1985·British Journal of Clinical Pharmacology·B SilkeS H Taylor
Jan 1, 1988·British Journal of Anaesthesia·S H Taylor, B Silke
Jan 1, 1987·European Journal of Clinical Pharmacology·N S Khurmi, E B Raftery
Feb 1, 1987·British Journal of Clinical Pharmacology·B SilkeS H Taylor
Dec 1, 1985·British Journal of Clinical Pharmacology·B SilkeS H Taylor
Mar 1, 1984·Anaesthesia·P HuttonC Prys-Roberts
Jan 1, 1994·Fundamental & Clinical Pharmacology·L RakotoarisoaC Mironneau
Jan 1, 1994·British Journal of Pharmacology·C D Drieu la RochelleS E O'Connor
May 1, 1994·European Heart Journal·D U AcharyaA Lahiri
Aug 1, 1995·Cardiovascular Drugs and Therapy·A KuhnU Tebbe