Hemodynamic effects of microbubble echo contrast

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
K Q SchwarzR Schlief

Abstract

The dose-related hemodynamic effects of an active (bubble-rich) echo contrast agent were compared with those of a bubble-free contrast agent and saline solution to determine whether the microbubbles contained in the echo contrast agent are truly passive indicators in the circulation or whether they actively alter the hemodynamic state independent of the volume and osmotic loading associated with such injections. The study population consisted of 13 fully instrumented open-chest mongrel dogs. Four hundred ninety-two bolus injections were made of three different types: active contrast agent (Levovist, Schering AG, Berlin) (n = 333), saline solution (n = 112), and bubble-free contrast agent (n = 47). Levovist was administered in five dose ranges spanning 0.013 to 0.341 gm/kg and, like the saline solution, was administered in bolus volumes of 0.053 to 1.136 ml/kg. For each injection type, the percent change in hemodynamic parameters after administration of the bolus were calculated on the basis of the dose or volume of the injectate. Audio Doppler signal intensity was used to document the presence of bubbles in the injectate. Statistical significance was defined at the p = 0.05 level; clinical significance was defined as a greater ...Continue Reading

References

Sep 1, 1992·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·R WalkerS B Feinstein
Feb 1, 1990·Journal of Cardiothoracic Anesthesia·C F HeidelmeyerM Schartl
Aug 1, 1990·Journal of the American College of Cardiology·S B FeinsteinP M Shah
Oct 1, 1994·Radiology·K Q SchwarzR Schlief
Oct 1, 1993·Journal of the American College of Cardiology·B GenyP Haberey

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Citations

Oct 31, 1998·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·K KrögerG Rudofsky
Jul 22, 1999·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·G SeidelM Kaps
Jan 24, 1998·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·H LambertzT Stein
May 11, 2000·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·K Q SchwarzC Brunelli
Jan 23, 2008·Journal of Cardiovascular Pharmacology·Dimitris BramosSavvas Toumanidis

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