PMID: 3744467Sep 1, 1986Paper

Hemodynamic effects of platelet activating factor in the dog kidney in vivo

Hypertension
H ScherfJ G Gerber

Abstract

The effect of platelet activating factor (PAF) on renal hemodynamics and function was examined in anesthetized dogs. The infusion of PAF into the renal artery at 5, 10, and 20 ng X min-1 X kg-1 body weight resulted in dose-dependent reductions in renal blood flow, glomerular filtration rate, urine volume, and urinary sodium excretion, whereas the infusion of vehicle alone in the contralateral kidney did not result in significant changes in these parameters. The maximum decrease expressed as the percent change from baseline was 22.2 +/- 1.7% for renal blood flow, 50.8 +/- 11% for glomerular filtration rate, 67.3 +/- 4.2% for urine volume, and 69.0 +/- 8.5% for urinary sodium excretion, respectively. These renal effects were not accompanied by significant alterations in systemic arterial blood pressure and heart rate. Pretreatment with indomethacin to block prostaglandin synthesis enhanced the effect of PAF on kidney function. Our data demonstrate that, unlike the rat kidney, intrarenal PAF infusion into the intact dog results in vasoconstriction and serve reduction in glomerular filtration rate.

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Citations

Mar 1, 1988·Seminars in Nephrology·W Schlueter, D C Batlle
Dec 1, 1991·Lipids·R RabinoviciG Feuerstein
Jan 1, 1991·Free Radical Biology & Medicine·J K BeckmanH L Greene
Dec 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D Van GoolH De Cuyper
Mar 12, 1997·European Journal of Pharmacology·T YatsuT Takenaka
Mar 1, 1989·Clinical and Experimental Pharmacology & Physiology·J F Gerkens
Dec 1, 1993·British Journal of Pharmacology·J G Filep, E Földes-Filep
Dec 1, 1988·Kidney International·U S SchwertschlagG Camussi
May 31, 1991·Biochemical and Biophysical Research Communications·T TakanoK Kurokawa
Oct 4, 2000·Physiological Reviews·G MontrucchioG Camussi
Oct 12, 1999·The American Journal of Physiology·S G Greenberg, K E Clark
Jan 17, 2003·American Journal of Physiology. Renal Physiology·Rajash K HandaShelly E Handa

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