Hemodynamic effects of pneumonia. II. Expansion of plasma volume

The Journal of Clinical Investigation
R KumarW H Abelmann


Previous work has demonstrated that approximately one-third of patients with pneumonia have a hypodynamic circulatory response. This response is characterized by an abnormally wide arteriovenous oxygen difference, a low cardiac output, increased peripheral resistance, and an increased hematocrit. This state was found to abate in convalescence. In an attempt to elucidate the pathogenesis of this hypodynamic state, nine additional patients were studied hemodynamically during the acute phase of pneumonia before and during acute expansion of blood volume by low molecular weight dextran (seven patients) or normal saline (two patients). Five patients were restudied before and during acute blood volume expansion in convalescence. Three patients with pneumonia had a normal arteriovenous oxygen difference (< 5.5 vol%), and six patients were hypodynamic in that their arteriovenous oxygen differences were greater than 5.5 vol%. With expansion of blood volume in the acute phase of pneumonia, all patients showed an increase in cardiac output, a decrease in arteriovenous oxygen difference, and a decrease in peripheral vascular resistance; however, the percentage change in the hypodynamic patients was not as great as occurred in the patients ...Continue Reading


Apr 1, 1970·The Journal of Clinical Investigation·H BensonW H Abelmann
Jun 1, 1967·Circulation Research·V S Bishop, H L Stone


May 15, 2009·Medicine·Vicente F Corrales-MedinaDaniel M Musher
Apr 1, 1970·The Journal of Clinical Investigation·H BensonW H Abelmann
Jan 22, 2013·Lancet·Vicente F Corrales-MedinaJulio A Chirinos
Nov 22, 2005·Annals of Tropical Paediatrics·Sunit SinghiS Majumdar
Jul 1, 1982·The American Journal of Medicine·G A ZimmermanM Cengiz
Jun 1, 1982·Circulation·A P Flessas, T J Ryan
Jan 1, 1972·British Heart Journal·D G Gibson, D J Coltart

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