Hemodynamic effects of sildenafil interaction with a nitric oxide donor compound in a dog model of acute pulmonary embolism

Life Sciences
Carlos A Dias-Junior, Jose E Tanus-Santos

Abstract

Sildenafil attenuates acute pulmonary embolism (APE)-induced pulmonary hypertension. However, the hemodynamic effects of sildenafil in combination with other vasodilators during APE have not been examined yet. In the present study, we examined the hemodynamic effects of combined diethylenetriamine/nonoate (DETA-NO, 1microMol kg(-1), i.v.) and sildenafil (0.25mg/kg, i.v.) in an anesthetized dog model of APE. Plasma nitrite/nitrate (NO(x)) and cyclic GMP concentrations were determined using an ozone-based chemiluminescence assay and a commercial enzyme immunoassay, respectively. We found that this dose of DETA-NO did not attenuate APE-induced pulmonary hypertension. However, significant decreases in mean pulmonary artery pressure were observed 15, 30 and 45min after the administration of sildenafil alone or after the combined administration of DETA-NO and sildenafil (all P<0.05). No significant differences among groups were observed in the respiratory parameters. While DETA-NO significantly increased NO(x) concentrations by approximately 4microM, cyclic GMP concentrations increased only when sildenafil was administered (all P<0.05). These results show that the combined administration of 1microMol kg(-1) of DETA-NO and sildenafil ...Continue Reading

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Citations

Jun 22, 2006·Intensive Care Medicine·Carlos A Dias-Junior
Nov 7, 2007·Pediatric Surgery International·Hüseyin UstünCankon Germiyanoğlu
Feb 19, 2011·The Kaohsiung Journal of Medical Sciences·Turgay AkgülCankon Germiyanoğlu
Sep 2, 2010·Nitric Oxide : Biology and Chemistry·Carlos A Dias-JuniorJose E Tanus-Santos
Feb 9, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Hugo J R BonattiKlaus D Hagspiel
Sep 16, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Juliana A UzuelliJose E Tanus-Santos
Mar 1, 2008·International Journal of Obstetric Anesthesia·Heitor Moreno
Dec 14, 2007·European Journal of Pharmacology·Stefany B A CauJose E Tanus-Santos
Dec 1, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Juliana A UzuelliJose E Tanus-Santos
Aug 19, 2007·Free Radical Biology & Medicine·Ingrid F MetzgerJose E Tanus-Santos
Aug 21, 2009·Journal of Veterinary Emergency and Critical Care·Robert GoggsDaniel L Chan
Oct 7, 2008·Basic & Clinical Pharmacology & Toxicology·Carlos A Dias-JuniorJose E Tanus-Santos
Feb 27, 2007·Respiratory Medicine·Carlos A Dias-Junior
Sep 29, 2011·European Journal of Pharmacology·Evandro M Neto-NevesJose E Tanus-Santos
Dec 3, 2010·Urologia Internationalis·Mustafa Okan IstanbulluogluYasar Ozgok
Oct 4, 2017·Pulmonary Circulation·Jacob SchultzJens Erik Nielsen-Kudsk
Jan 30, 2019·Pharmacology Research & Perspectives·Kristofer F Nilsson, Lars E Gustafsson
Mar 18, 2020·Pulmonary Circulation·Mads Dam LyhneAsger Andersen
Jul 7, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Haitao FengYoshiki Katayama

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