Hemodynamic effects of synthetic atrial natriuretic factor (ANF) in dogs with acute left ventricular failure

European Journal of Pharmacology
C S SweetE H Blaine

Abstract

The hemodynamic and renal electrolyte/function effects of a synthetic peptide (ANF) corresponding to the sequence of the 26 amino acids contained in atrial natriuretic factor (ANF) were assessed in closed-chest dogs in which acute left ventricular failure was produced by coronary artery embolization with 50 micron plastic microspheres. Coronary embolization produced a sustained reduction in cardiac contractility (LV dP/dtmax) and cardiac output which averaged 42 and 44%, respectively. Following a 45 min equilibration period after heart failure induction, most of the hemodynamic functions stabilized. At this time, ANF infused intravenously at 100 pmol/kg per min X 30 min (n = 9) did not lower mean arterial pressure although it increased cardiac output (P less than 0.05) by 17% at only one time period. With the exception of a fall in coronary resistance and an increase in myocardial blood flow, a higher dose of ANF (200 pmol/kg per min) did not consistently alter hemodynamic function. Fractional excretion of sodium (FE Na%) increased 3.4-fold with ANF at 100 pmol/kg per min and 1.8-fold with the 200 pmol/kg per min dose. Neither dose of ANF produced significant effects on renal blood flow (RBF) or glomerular filtration rate (GFR)...Continue Reading

References

Sep 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·A J De Bold
Jan 7, 1985·Life Sciences·A A SeymourR F Nutt
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N G SeidahT A Lyle
Jun 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M B PamnaniF J Haddy
Nov 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J NussbergerE Haber
Feb 24, 1984·Science·J E ChimoskeyS R Heidemann
May 16, 1984·Biochemical and Biophysical Research Communications·M A NapierE H Blaine
Jun 15, 1984·European Journal of Pharmacology·R J WinquistR F Nutt
Mar 1, 1983·Hypertension·N C TrippodoF E Cole
Sep 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·N C TrippodoH L Blakesley
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·A J de Bold

❮ Previous
Next ❯

Citations

Aug 15, 1986·Klinische Wochenschrift·H J Kramer, B Lichardus
Nov 17, 1987·European Journal of Pharmacology·R W WatkinsR P Tedesco
Aug 11, 1987·European Journal of Pharmacology·T TikkanenF Fyhrquist
Nov 29, 1986·Lancet·I G CrozierN J Warner
Aug 1, 1992·European Journal of Clinical Investigation·G ErtlK Kochsiek
Jul 15, 1993·International Journal of Cardiology·P Di NardoG Tallarida
Jun 1, 1988·Hypertension·T H Steele, L Challoner-Hue
Jun 1, 1986·Hypertension·J P GrangerJ C Burnett
Jan 1, 1988·Circulation Research·R J BacheD G Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.