Hemodynamic effects of synthetic atrial natriuretic factor (ANF) in dogs with acute left ventricular failure

European Journal of Pharmacology
C S SweetE H Blaine


The hemodynamic and renal electrolyte/function effects of a synthetic peptide (ANF) corresponding to the sequence of the 26 amino acids contained in atrial natriuretic factor (ANF) were assessed in closed-chest dogs in which acute left ventricular failure was produced by coronary artery embolization with 50 micron plastic microspheres. Coronary embolization produced a sustained reduction in cardiac contractility (LV dP/dtmax) and cardiac output which averaged 42 and 44%, respectively. Following a 45 min equilibration period after heart failure induction, most of the hemodynamic functions stabilized. At this time, ANF infused intravenously at 100 pmol/kg per min X 30 min (n = 9) did not lower mean arterial pressure although it increased cardiac output (P less than 0.05) by 17% at only one time period. With the exception of a fall in coronary resistance and an increase in myocardial blood flow, a higher dose of ANF (200 pmol/kg per min) did not consistently alter hemodynamic function. Fractional excretion of sodium (FE Na%) increased 3.4-fold with ANF at 100 pmol/kg per min and 1.8-fold with the 200 pmol/kg per min dose. Neither dose of ANF produced significant effects on renal blood flow (RBF) or glomerular filtration rate (GFR)...Continue Reading


Sep 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·A J De Bold
Jan 7, 1985·Life Sciences·A A SeymourR F Nutt
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N G SeidahT A Lyle
Jun 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M B PamnaniF J Haddy
Nov 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J NussbergerE Haber
Feb 24, 1984·Science·J E ChimoskeyS R Heidemann
May 16, 1984·Biochemical and Biophysical Research Communications·M A NapierE H Blaine
Jun 15, 1984·European Journal of Pharmacology·R J WinquistR F Nutt
Mar 1, 1983·Hypertension·N C TrippodoF E Cole
Sep 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·N C TrippodoH L Blakesley
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·A J de Bold

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Aug 15, 1986·Klinische Wochenschrift·H J Kramer, B Lichardus
Nov 17, 1987·European Journal of Pharmacology·R W WatkinsR P Tedesco
Aug 11, 1987·European Journal of Pharmacology·T TikkanenF Fyhrquist
Nov 29, 1986·Lancet·I G CrozierN J Warner
Aug 1, 1992·European Journal of Clinical Investigation·G ErtlK Kochsiek
Jul 15, 1993·International Journal of Cardiology·P Di NardoG Tallarida
Jun 1, 1988·Hypertension·T H Steele, L Challoner-Hue
Jun 1, 1986·Hypertension·J P GrangerJ C Burnett
Jan 1, 1988·Circulation Research·R J BacheD G Chen

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