Hemodynamic effects of the somatostatin analog lanreotide in humans: placebo-controlled, cross-over dose-ranging Echo-Doppler study

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
C MottetC Beglinger

Abstract

Because of their vasoactive effects, somatostatin and its analogs are increasingly used in the management of complications of chronic liver diseases such as variceal bleeding. Postprandial hyperemia augments splanchnic blood flow, subsequently increasing portal pressure. The aim of this study was to explore effects of the somatostatin analog, lanreotide, on food-stimulated hemodynamic parameters in healthy human subjects. A dose-response curve was constructed in eight healthy male subjects in a placebo-controlled cross-over study. On 4 different days, either 0 (placebo), 50, 100, or 200 microg/h of lanreotide was infused intravenously in random order, starting at 45 minutes for 7 hours. On each day, a liquid test meal (Ensure plus, 1.5 kcal/mL) was perfused intraduodenally at a rate of 3 mL/min over 7 hours after a 45-minute basal period. Diastolic arterial pressure (dBP), heart rate (HR), superior mesenteric arterial (SMA) average flow velocity (SMA-V), SMA pulsatility index (SMA-PI), portal venous volume flow (PV-F), and renal artery (RA) resistance index (RA-RI) were measured on regular intervals (flows using Echo-Doppler technology). Lanreotide at all doses abolished food-stimulated splanchnic hyperemia both in the SMA and ...Continue Reading

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Citations

May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D E Newby, R Jalan
Sep 18, 2001·Journal of the American Geriatrics Society·O StaneczekC C Sieber
Jan 12, 2008·World Journal of Gastroenterology : WJG·Osman OzdoganNurdan Tozun
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Feb 4, 2009·Toxicologic Pathology·Monique Y WellsPhilippe Picaut
Oct 7, 2006·Current Opinion in Gastroenterology·G Garcia-Tsao

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