Hemodynamic, hormonal, and renal effects of intracerebroventricular adrenomedullin in conscious sheep

Endocrinology
Christopher J CharlesM Gary Nicholls

Abstract

Adrenomedullin, the recently described vasodilator that exhibits potent hypotensive actions when administered systemically, is also found in the central nervous system, suggesting a role for adrenomedullin as a neurohormone. However, only a limited number of studies have examined the central effects of adrenomedullin. Therefore, we have examined the integrative hemodynamic, renal, and hormonal effects of intracerebroventricular (I.C.V.) adrenomedullin in conscious sheep. Eight surgically prepared sheep received I.C.V. infusions of adrenomedullin at two doses (2 ng/kg x min followed immediately by 20 ng/kg x min each for 90 min) in a vehicle-controlled study. Water deprivation for 48 h before control infusion resulted in sheep drinking 2617 +/- 583 ml in the 90-min period following reintroduction of water. On the adrenomedullin day, drinking was halved to 1392 +/- 361 ml (P < 0.05). Adrenomedullin had no significant effect on urinary volume and sodium excretion. Plasma adrenomedullin levels remained unchanged during control infusions but were elevated by the end of I.C.V. adrenomedullin infusions (P < 0.001). Plasma ANP levels were also increased approximately 50% (P < 0.05). Plasma levels of both ACTH and cortisol were also inc...Continue Reading

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Citations

Nov 19, 2003·Biochemical and Biophysical Research Communications·Maho OgoshiYoshio Takei
May 23, 2007·Heart Failure Reviews·Dwaine S BurleyGary F Baxter
Jan 27, 2005·Pharmacology & Therapeutics·Shabaz A Hamid, Gary F Baxter
Oct 7, 2004·Pharmacology & Therapeutics·David C BuntonJohn J V McMurray
Oct 12, 2000·Journal of Cardiovascular Pharmacology·C J CharlesM G Nicholls
Apr 27, 2000·Endocrine Reviews·J P HinsonD M Smith
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Mario A GarcíaAlfredo Martínez

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