Hemodynamic impact of a positive end-expiratory pressure setting in acute respiratory distress syndrome: importance of the volume status

Critical Care Medicine
Emilie FougèresXavier Monnet

Abstract

The hemodynamic impact of positive end-expiratory pressure in acute respiratory distress syndrome and the underlying mechanisms have not been extensively investigated during low stretch ventilation. Our aim was to evaluate the hemodynamic effect of increasing positive end-expiratory pressure when tidal volume and the plateau pressure are limited and to explore the underlying mechanisms. Prospective study. Medical intensive care unit. Twenty-one acute respiratory distress syndrome patients ventilated with a tidal volume of 6.0 +/- 0.5 mL/kg of predicted body weight. Positive end-expiratory pressure was significantly increased from 5 +/- 1 cm H2O to 13 +/- 4 cm H2O for reaching a plateau pressure of 30 +/- 1 cm H2O. At high positive end-expiratory pressure, passive leg raising was performed for increasing the central blood volume. We performed echocardiography and pulmonary artery catheterization during positive end-expiratory pressure increase and during passive leg raising at high positive end-expiratory pressure. With positive end-expiratory pressure elevation, the cardiac index decreased by 13% +/- 9%. The right ventricular end-diastolic area, right atrial pressure, and pulmonary vascular resistance increased by 13% +/- 20%, ...Continue Reading

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