Hemodynamic-independent anti-natriuretic effect of urotensin II in spontaneously hypertensive rats

Peptides
Ying ShiYi-Chun Zhu

Abstract

The present study aims to test the hypothesis that U-II might have a direct anti-natriuretic action in spontaneously hypertensive rats (SHR). Bolus U-II injection (15 nmol kg(-1)) caused a transient decrease in glomerular filtration rate (GFR), urine flow rate (UV), urinary sodium (UNaV) and potassium excretion (U(K)V) that corresponded with a committed decrease in mean arterial pressure (MAP) and renal blood flow (RBF) during the first 30 min. Continuous U-II infusion (0.2 nmol kg(-1)h(-1)) following a bolus U-II injection (0.3 nmol kg(-1)) caused an anti-natriuretic effect without any significant change in MAP, RBF, GFR, UV and UKV during the entire 1.5-h perfusion period in SHR. The levels of aldosterone and angiotensin II were not altered in the plasma and kidney, while plasma antidiuretic hormone decreased in response to U-II injection (15 nmol kg(-1)). Protein levels of U-II receptors (UT) were significantly increased in the kidney of 17-week-old SHR when compared with the age-matched WKY rats, while mRNA transcripts of both U-II and UT were increased in the kidney, left ventricle and thoracic aorta. In conclusion, U-II exerts a hemodynamic-independent anti-natriuretic action in adult SHR. The anti-natriuretic action of U...Continue Reading

References

Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D PearsonH A Bern
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y CoulouarnH Vaudry
Aug 22, 2000·British Journal of Pharmacology·F E BottrillR White
Jan 13, 2001·British Journal of Pharmacology·F D RussellD M O'Brien
Jun 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Andre ShenoudaAdel Giaid
May 31, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Lei LüYi-Chun Zhu
Jun 5, 2003·American Journal of Physiology. Renal Physiology·Andrew Y ZhangAi-Ping Zou
Dec 4, 2003·British Journal of Pharmacology·Riccardo PatacchiniCarlo Alberto Maggi
Jun 18, 2004·Journal of Hypertension·Bernard M Y CheungLouisa Y F Wong
Sep 15, 2004·European Journal of Pharmacology·Valeria CamardaDavid G Lambert
May 14, 2005·Annals of the New York Academy of Sciences·R J BalmentN Ashton
Mar 15, 2006·Kidney International·W SongN Ashton

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Citations

Jul 14, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ari MosenkisRaymond R Townsend
Jan 7, 2014·PloS One·Radoslaw DebiecMaciej Tomaszewski
Apr 5, 2013·The Journal of Endocrinology·Hitesh Soni, Adebowale Adebiyi
Feb 14, 2012·Experimental Physiology·Ellen J Forty, Nick Ashton
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Alaa E S Abdel-RazikNick Ashton
Jan 5, 2019·Journal of Cardiovascular Pharmacology·Mina NishiTakahiro Nagayama

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