Hemodynamic influences of azelnidipine, a novel calcium channel blocker, on cerebral circulation in hypertensive patients with ischemic white matter lesions

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yasuyuki KimuraJun Hatazawa

Abstract

Calcium channel blockers have been widely used for the treatment of hypertension because several clinical trials have demonstrated their strong action on lowering blood pressure and their role in preventing cardiovascular events such as stroke and coronary heart disease. However, there have been few reports on the effects on cerebral hemodynamics when blood pressure is lowered with this class of drug. In this study, we used positron emission tomography and acetazolamide challenge tests to measure cerebral blood flow and cerebrovascular reserve before and after administration of a novel calcium channel blocker, azelnidipine, in nine hypertensive patients (mean age, 66.1 years) with ischemic white matter lesions. Systemic blood pressure was significantly decreased from baseline (153.8+/-15.5/92.1+/-8.5 mmHg) after treatment with azelnidipine (138.4+/-16.3/81.8+/-6.2 mmHg). The baseline global cerebral blood flow values before and after treatment were 40.1+/-7.2 mL/min/100 g and 39.2+/-8.2 mL/min/100 g, respectively. The cerebrovascular reserve values before and after treatment were 58.6+/-21.7% and 56.3+/-21.3%, respectively. Differences in these parameters were not significant. A regional analysis showed no statistical differenc...Continue Reading

References

Apr 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I KannoK Uemura
Aug 1, 1984·The American Journal of Physiology·C W Haws, D D Heistad
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·M KasteS Sarna
Feb 22, 2001·Neurobiology of Aging·E FarkasP G Luiten
Feb 24, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·E Eleuteri
Mar 29, 2001·Clinical and Experimental Hypertension : CHE·M SabbatiniF Amenta
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Apr 5, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shoji SuzukiIwao Yamaguchi
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerUNKNOWN Rotterdam Scan Study
Jun 11, 2005·Brain : a Journal of Neurology·Niels D PrinsMonique M B Breteler
Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naohiko OkuJun Hatazawa
May 11, 2006·Cerebrovascular Diseases·Bruce Ovbiagele, Jeffrey L Saver
Jan 4, 2008·Hypertension·Toshio OgiharaUNKNOWN Candesartan Antihypertensive Survival Evaluation in Japan Trial Group
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazunori Toyoda
Apr 10, 2008·Journal of Hypertension·Dimitris P Papadopoulos, Vasilios Papademetriou
Jun 5, 2008·Cell Metabolism·Costantino Iadecola, Robin L Davisson

❮ Previous
Next ❯

Citations

Jul 4, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuo KitagawaSaburo Sakoda
Nov 6, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Osian LlwydMartin Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Naohiko OkuJun Hatazawa
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
H KanaiY Kuwabara
© 2021 Meta ULC. All rights reserved