Hemodynamic, morphometric and autonomic patterns in hypertensive rats - Renin-Angiotensin system modulation.

Clinics
F S ZamoM C Irigoyen

Abstract

Spontaneously hypertensive rats develop left ventricular hypertrophy, increased blood pressure and blood pressure variability, which are important determinants of heart damage, like the activation of renin-angiotensin system. To investigate the effects of the time-course of hypertension over 1) hemodynamic and autonomic patterns (blood pressure; blood pressure variability; heart rate); 2) left ventricular hypertrophy; and 3) local and systemic Renin-angiotensin system of the spontaneously hypertensive rats. MALE SPONTANEOUSLY HYPERTENSIVE RATS WERE RANDOMIZED INTO TWO GROUPS: young (n=13) and adult (n=12). Hemodynamic signals (blood pressure, heart rate), blood pressure variability (BPV) and spectral analysis of the autonomic components of blood pressure were analyzed. LEFT ventricular hypertrophy was measured by the ratio of LV mass to body weight (mg/g), by myocyte diameter (mum) and by relative fibrosis area (RFA, %). ACE and ACE2 activities were measured by fluorometry (UF/min), and plasma renin activity (PRA) was assessed by a radioimmunoassay (ng/mL/h). Cardiac gene expressions of Agt, Ace and Ace2 were quantified by RT-PCR (AU). The time-course of hypertension in spontaneously hypertensive rats increased BPV and reduced ...Continue Reading

Citations

Apr 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Amy C ArnoldDebra I Diz
Jul 17, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Julia ZimmerBeate Rassler
Sep 2, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T FernandesE M Oliveira
Dec 6, 2018·American Journal of Physiology. Renal Physiology·Lectícia B JorgeLucia Andrade
May 9, 2012·European Journal of Applied Physiology·Jacqueline F MachiRogério B Wichi
Dec 15, 2020·Scientific Reports·Nathalia Juocys Dias MoreiraMaria Cláudia Costa Irigoyen
Aug 20, 2020·Molecular and Cellular Endocrinology·Elder Sales da SilvaCarlos Henrique Xavier

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Methods Mentioned

BETA
light microscopy
Protein Assay
PCR

Software Mentioned

BLAST
Primer3

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