PMID: 7333717Jan 1, 1981Paper

Hemodynamic pattern following K-strophanthin in normal and coronary artery disease patients

International Journal of Cardiology
M Di DonatoF Fantini

Abstract

Hemodynamic effects of K-strophanthin (0.005 mg/kg i.v.) were evaluated in 7 normal and in 13 non-failing coronary artery disease patients (CAD). Volumetric parameters were obtained by single plane left ventricular angiography. The indexes of "pump" function, the end-systolic pressure-volume relationship and the ratio of peak pressure to systolic volume were also evaluated. Heart rate was maintained constant by atrial pacing. In normal subjects K-strophanthin exerted small effects without peripheral vasoconstriction. CAD patients showed different response to K-strophanthin in vascular tone: an increase (Group 1) or a decrease (Group 2) in total systemic resistance (TSR). No significant differences were found in basal values between the two CAD groups. In Group 2 the indexes of "pump" function increased after K-strophanthin and the end-systolic pressure-volume points shifted upward and to the left, while in Group 1 no improvement in cardiac function was observed and the end-systolic pressure-volume points shifted upward and to the right. Furthermore, we found a direct significant correlation between the percent changes of TSR and end-systolic volume index, and a negative significant correlation between the percent changes of TSR...Continue Reading

References

May 1, 1979·The American Journal of Cardiology·J H KleimanE B Stinson
Dec 1, 1979·The American Journal of Cardiology·J D MarshW Grossman
Dec 1, 1977·Circulation Research·L D HorwitzM Saito
Jun 1, 1976·The Journal of the Louisiana State Medical Society : Official Organ of the Louisiana State Medical Society·M Finn, B F Jacobs
Sep 14, 1972·The New England Journal of Medicine·S H RahimtoolaR M Gunnar
Mar 1, 1973·The American Journal of Cardiology·K E Hammermeister, J R Warbasse
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Jun 1, 1960·The Journal of Clinical Investigation·J ROSSE BRAUNWALD
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