Hemodynamic, platelet and clinical responses to prostacyclin in unstable angina pectoris

The American Journal of Cardiology
P ThérouxD Waters

Abstract

The hemodynamic and platelet effects of prostacyclin (PGI2) were investigated in 27 patients with unstable angina (14 treated patients; 13 control subjects) given a 72-hour infusion (5 ng/kg/min) or placebo. This randomized study was double-blind and conducted as a substudy of a multicenter trial testing the clinical efficacy of PGI2. The clinical and angiographic features were identical in the 2 groups. Blood pressure and heart rate were not modified significantly by PGI2. A recurrence of angina during infusion occurred in 8 treated patients (57.1%) and in 8 control subjects (61.5%). Two patients receiving PGI2 and none in the control group developed a myocardial infarction. Levels of 6-keto-prostaglandin F1 alpha, a stable metabolite of PGI2, increased from baseline values (less than 20 pg/ml) to 605 +/- 41 pg/ml during infusion. Levels of fibrinopeptide A, beta-thromboglobulin, platelet factor 4, thromboxane B2 and the platelet aggregates ratio in blood were similar between the 2 groups before, during and after PGI2 infusion. Prostacyclin reduced ex vivo platelet aggregation to adenosine diphosphate and thromboxane B2 generation by approximately 50% during the infusion period with return of aggregation to baseline and platel...Continue Reading

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Citations

Mar 1, 1990·Journal of the American College of Cardiology·J L Mehta
Mar 1, 1993·Current Problems in Cardiology·P Théroux, R M Lidón
Mar 3, 1998·Blood Reviews·J E Joseph, S J Machin
Nov 4, 1991·The American Journal of Cardiology·D WatersP Théroux
Sep 3, 1991·The American Journal of Cardiology·P Théroux

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