PMID: 9149295Jan 1, 1997

Hemodynamic profile of neuropeptide Y in dogs: effect of ganglionic blockade

Peptides
M A HashimA S Tadepalli

Abstract

The hemodynamic effects of neuropeptide Y (NPY) were examined over a dose range of 0.03-30 nmol/kg, i.v., in anesthetized open-chest, ventilated dogs with and without ganglionic blockade. In normal (non-ganglion-blocked) animals, NPY produced significant, dose-dependent, and sustained (lasting 15-45 min) increases in mean arterial blood pressure and systemic vascular resistance (SVR) with a threshold dose of 0.3 nmol/kg and a maximum effective dose of 10 nmol/kg. Cardiac index (CI) decreased at doses > 1 nmol/kg, but stroke volume was not altered; heart rate (HR) decreased significantly at and above the 3 nmol/kg dose. No significant changes were observed in the left ventricular dP/dt (LVdP/dt) or the contractility index (LVdP/dt divided by systolic pressure). In ganglion-blocked animals, pressor and SVR responses to NPY were similar to those seen in normal animals but HR was not affected and a small but significant decrease in CI was seen only at the 30 nmol/kg. Furthermore, whereas LVdP/dt of ganglion-blocked dogs increased significantly at and above the 1 nmol/kg dose, the contractility index increased slightly only with the 10 and 30 nmol/kg doses. These data indicate that NPY produces sustained hypertension in dogs seconda...Continue Reading

References

Sep 1, 1991·British Journal of Pharmacology·S J AwadD P Richardson
Mar 1, 1991·Trends in Pharmacological Sciences·P WalkerB Waeber
Apr 1, 1987·Acta Physiologica Scandinavica·C WahlestedtR Håkanson
Mar 1, 1987·Clinical and Experimental Pharmacology & Physiology·R B MinsonJ P Chalmers
Nov 1, 1995·Neuropeptides·M A Hashim, A S Tadepalli
May 1, 1996·Journal of Cardiovascular Pharmacology·A S TadepalliA J Daniels

Citations

Mar 17, 1999·Heart & Lung : the Journal of Critical Care·M K BaigM Gheorghiade
Jun 18, 1998·American Heart Journal·M K BaigM Gheorghiade

Related Concepts

Ascending Aorta Structure
Diastolic Blood Pressure
Cardiac Output
Canis familiaris
Dose-Response Relationship, Drug
Structure of Parasympathetic Ganglion
Pulse Rate
Hemodynamics
Neuropeptide Y Like Immunoreactive Peptide
Regional Blood Flow

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