Oct 6, 2015

Hemodynamic response function in resting brain: disambiguating neural events and autonomic effects

BioRxiv : the Preprint Server for Biology
Guorong Wu, Daniele Marinazzo

Abstract

It has been shown that resting state brain dynamics can be characterized by looking at sparse blood-oxygen-level dependent (BOLD) events, which can be retrieved by point process analysis. Cardiac activity can also induce changes in the BOLD signal, thus affect both the number of these events and the mapping between neural events and BOLD signal, namely the hemodynamic response. To isolate neural activity and autonomic effects, we compare the resting state hemodynamic response retrieved by means of a point process analysis with and without deconvolving the cardiac fluctuations. Brainstem and the surrounding cortical area (such as precuneus, insula etc.) are found to be significantly affected by cardiac pulses. Methodological and physiological implications are then discussed.

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Mentioned in this Paper

Fluctuation
Physiologic Pulse
Entire Brainstem
Neuroma
Brain
Structure of Cortex of Kidney
Isolate compound
Heart
Entire Insula
Analysis

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