Hemodynamic Response of the Three Macular Capillary Plexuses in Dark Adaptation and Flicker Stimulation Using Optical Coherence Tomography Angiography

Investigative Ophthalmology & Visual Science
Peter L NesperAmani A Fawzi

Abstract

To assess retinal microvascular reactivity during dark adaptation and the transition to ambient light and after flicker stimulation using optical coherence tomography angiography (OCTA). Fifteen eyes of 15 healthy participants were dark adapted for 45 minutes followed by OCTA imaging in the dark-adapted state. After 5 minutes of normal lighting, subjects underwent OCTA imaging. Participants were then subjected to a flashing light-emitting diode (LED) light and repeat OCTA. Parafoveal vessel density and adjusted flow index (AFI) were calculated for superficial (SCP), middle (MCP), and deep capillary plexuses (DCP), and then compared between conditions after adjusting for age, refractive error, and scan quality. SCP vessel length density (VLD) was also evaluated. Between-condition capillary images were aligned and subtracted to identify differences. We then analyzed images from 10 healthy subjects during the transition from dark adaptation to ambient light. SCP vessel density was significantly higher while SCP VLD was significantly lower during ambient light and flicker compared to dark adaptation. There was a significant positive mean value for DCP "flicker minus dark or light," suggesting more visible vessels during flicker due...Continue Reading

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Citations

Jun 7, 2020·Journal of Clinical Medicine·Jacqueline ChuaLeopold Schmetterer
Jun 21, 2020·Investigative Ophthalmology & Visual Science·Diogo CabralK Bailey Freund
Dec 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Martin KallabGerhard Garhöfer
Aug 14, 2020·Progress in Retinal and Eye Research·Jackson ScharfDavid Sarraf
May 1, 2021·Journal of Clinical Medicine·Swetapadma TripathyManjot K Gill
Sep 4, 2020·American Journal of Ophthalmology·Ramesh VenkateshNaresh Kumar Yadav

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Software Mentioned

SSADA
OCTA
SPSS
ImageJ
Optovue
SAS
AngioVue Analytics
PAR
bUnwarpJ

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