Hemodynamic response to hyperventilation test in healthy volunteers

Clinical Cardiology
D AlexopoulosA G Vagenakis

Abstract

Hyperventilation is well known to affect the electrocardiogram (ECG) in subjects without heart disease and produce spasm in patients with variant angina. The autonomic nervous system is thought to play a significant role in these effects. However, the normal hemodynamic response to hyperventilation is not well defined. We subjected 369 healthy volunteers (200 men, 169 women) to prolonged hyperventilation (30 respirations for 5 min and 10 min recovery) under continuous ECG monitoring and to exercise testing. Heart rate (HR), systolic and diastolic blood pressures (SBP, DBP) and rate-pressure product were recorded. Hyperventilation resulted in an immediate (within the first min), significant increase in HR by 27.4%, a further small increase at min 2 of hyperventilation, and a subsequent small decrease in HR at mins 3-5. An immediate drop of HR by 20.1% was observed with discontinuation of hyperventilation. Apart from a slightly higher HR increase in men, a similar pattern of HR changes was found in both genders. On multivariate analysis, younger age, absence of smoking, and male gender were associated with a higher HR increase with hyperventilation (p < 0.0001, p < 0.0001, and p < 0.001, respectively). SBP and DBP increased with ...Continue Reading

References

May 1, 1991·The American Journal of the Medical Sciences·J OnrotD Robertson
Jan 1, 1989·The American Journal of Cardiology·D ArdissinoC Montemartini
Jan 1, 1989·The American Journal of Cardiology·M PrevitaliJ A Salerno
Mar 1, 1989·Journal of the American College of Cardiology·P C HanleyR J Gibbons
Mar 15, 1989·Journal of the American College of Cardiology·D ArdissinoC Montemartini
Mar 1, 1987·The American Journal of Cardiology·D ArdissinoC Montemartini
May 1, 1986·American Heart Journal·M S GreenY Luz
Apr 1, 1985·Journal of the Autonomic Nervous System·F LioyC Garneau
Feb 1, 1971·American Heart Journal·L BibermanB Surawicz
Nov 1, 1984·Journal of the American College of Cardiology·L W Klein
Jan 1, 1984·Circulation·T A Davidowski, S Wolf
Sep 1, 1984·Circulation·M B HigginbothamF R Cobb
Feb 1, 1983·Journal of the American College of Cardiology·L W KleinL E Teichholz
Mar 1, 1982·The American Journal of Cardiology·L A GirottiM B Rosenbaum
Jan 1, 1962·American Heart Journal·G G ROWEC W CRUMPTON

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Citations

Apr 20, 2005·Journal of Human Hypertension·J E NaschitzI Rosner
Oct 9, 2008·Experimental Eye Research·Subha T VenkataramanJohn G Flanagan
Jul 12, 2017·Scientific Reports·Masahiro HoriuchiHerman Pontzer
Dec 1, 2019·Scientific Reports·Selwynne M HawkinsKady Fischer
Oct 13, 2020·Frontiers in Physiology·Dominik SchüttlerWolfgang Hamm

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