Hemodynamic shear stresses in mouse aortas: implications for atherogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology
Jin SuoDon P Giddens

Abstract

The hemodynamic environment is a determinant of susceptibility to atherosclerosis in the vasculature. Although mouse models are commonly used in atherosclerosis studies, little is known about local variations in wall shear stress (WSS) in the mouse and whether the levels of WSS are comparable to those in humans. The objective of this study was to determine WSS values in the mouse aorta and to relate these to expression of gene products associated with atherosclerosis. Using micro-CT and ultrasound methodologies we developed a computational fluid dynamics model of the mouse aorta and found values of WSS to be much larger than those for humans. We also used a quantum dot-based approach to study vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression on the aortic intima and demonstrated that increased expression for these molecules occurs where WSS was relatively low for the mouse. Despite large differences in WSS in the two species, the spatial distributions of atherogenic molecules in the mouse aorta are similar to atherosclerotic plaque localization found in human aortas. These results suggest that relative differences in WSS or in the direction of WSS, as opposed to the absolute magnitude, may be re...Continue Reading

References

May 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D N KuS Glagov
Feb 16, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C G CaroR C Schroter
Jul 1, 1995·Physiological Reviews·P F Davies
Feb 15, 1993·Biochemical and Biophysical Research Communications·J AndoA Kamiya
Mar 27, 2001·Current Opinion in Lipidology·C A Reardon, G S Getz
May 2, 2003·Annals of Biomedical Engineering·Dehong ZengC Ross Ethier
Aug 22, 2003·Journal of Biomechanical Engineering·Suo JinDon P Giddens
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Craig L DuvallRobert E Guldberg
Oct 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dardo E FerraraW Robert Taylor
May 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Joan M GreveCharles A Taylor
Oct 19, 2006·Journal of Biomechanics·Peter D Weinberg, C Ross Ethier

❮ Previous
Next ❯

Citations

Apr 2, 2009·Annals of Biomedical Engineering·Yajuan WangKerem Pekkan
May 28, 2009·Annals of Biomedical Engineering·Juan M Jiménez, Peter F Davies
Jul 16, 2013·Differentiation; Research in Biological Diversity·Hyun Jung LeePamela L Wenzel
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Peter F Davies
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Won Jong RheeGang Bao
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zhen ChenJohn Y-J Shyy
May 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jing ZhouJeng-Jiann Chiu
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicholas S KirkbyJane A Mitchell
Sep 17, 2008·Computer Methods in Biomechanics and Biomedical Engineering·Patrick W Alford, Larry A Taber
Feb 4, 2009·Antioxidants & Redox Signaling·Hanke L MatlungEd VanBavel
Aug 18, 2010·Antioxidants & Redox Signaling·Amir RezvanHanjoong Jo
Aug 18, 2010·Antioxidants & Redox Signaling·Nick J WillettW Robert Taylor
Jan 8, 2009·Cardiovascular Research·Daniel E ConwayLarry V McIntire
Apr 18, 2013·Cardiovascular Research·Kim Van der HeidenPaul C Evans
May 20, 2011·Journal of the Royal Society, Interface·P E VincentS J Sherwin
Jul 6, 2012·Journal of the Royal Society, Interface·Mark A Van DoormaalC Ross Ethier
Jun 9, 2010·Journal of Biomechanical Engineering·Hui ZhuMorton H Friedman
Apr 30, 2009·Annual Review of Biomedical Engineering·C A Taylor, C A Figueroa
Jun 18, 2010·American Journal of Physiology. Cell Physiology·Benoît Melchior, John A Frangos
Sep 24, 2010·American Journal of Physiology. Cell Physiology·Daniel E ConwayLarry V McIntire
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Douglas NamHanjoong Jo
Dec 4, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Ian C CampbellW Robert Taylor
Apr 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Robert D ShepherdKristina D Rinker
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Smbat AmirbekianJohn N Oshinski
Feb 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·S C NewcomerC A Ray
Nov 16, 2010·Journal of Biomedicine & Biotechnology·Andrew R Bond, Christopher L Jackson
Aug 4, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sarah L TresselHanjoong Jo
Aug 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Reema GoelDebra K Newman
Apr 23, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Li LiDavid G Harrison
Mar 9, 2011·The Journal of Clinical Investigation·Kel Vin WooH Scott Baldwin
Nov 5, 2008·Journal of Lipid Research·Linda K Curtiss, Peter S Tobias
Dec 3, 2008·Disease Models & Mechanisms·Hazel Y StevensJohn A Frangos
Oct 5, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gérard FinetGhassan S Kassab
Feb 18, 2009·Computer Methods in Biomechanics and Biomedical Engineering·Bram TrachetPatrick Segers
Jan 17, 2016·Antioxidants & Redox Signaling·Neil BowdenPaul Evans
Dec 2, 2010·IEEE Transactions on Bio-medical Engineering·Kenichi FunamotoTomoyuki Yambe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Akiva FeintuchC Ross Ethier
JAMA : the Journal of the American Medical Association
A M MalekS Izumo
Proceedings of the National Academy of Sciences of the United States of America
Anthony G PasseriniPeter F Davies
© 2021 Meta ULC. All rights reserved