Hemodynamics in the Left Atrium and Its Effect on Ventricular Flow Patterns

Journal of Biomechanical Engineering
Vijay VedulaRajat Mittal

Abstract

In the present study, we investigate the hemodynamics inside left atrium (LA) and understand its impact on the development of ventricular flow patterns. We construct the heart model using dynamic-computed tomographic images and perform simulations using an immersed boundary method based flow solver. We show that the atrial hemodynamics is characterized by a circulatory flow generated by the left pulmonary veins (LPVs) and a direct stream from the right pulmonary veins (RPVs). The complex interaction of the vortex rings formed from each of the PVs leads to vortex breakup and annihilation, thereby producing a regularized flow at the mitral annulus. A comparison of the ventricular flow velocities between the physiological and a simplified pipe-based atrium model shows that the overall differences are limited to about 10% of the peak mitral flow velocity. The implications of this finding on the functional morphology of the left heart as well the computational and experimental modeling of ventricular hemodynamics are discussed.

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Citations

Nov 4, 2016·Annals of Biomedical Engineering·Tomohiro OtaniHiroshi Ashikaga
Sep 24, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mohamad LazkaniAshish Pershad
Oct 27, 2018·Annals of Biomedical Engineering·Jonas LantzTino Ebbers
Aug 23, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Jahanbakhsh JahanzaminAbbas Nasiraei-Moghaddam
Jul 12, 2017·Cardiovascular Engineering and Technology·Yifan WangStephen H Little
May 8, 2018·International Journal for Numerical Methods in Biomedical Engineering·Guadalupe García-IslaOscar Camara
Aug 28, 2019·International Journal for Numerical Methods in Biomedical Engineering·Liuyang FengXiaoyu Luo
Jan 9, 2019·Frontiers in Physiology·Desmond Dillon-MurphyAdelaide de Vecchi
Mar 27, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Jung Hee SeoRajat Mittal
Mar 7, 2019·Journal of Biomechanical Engineering·Parastou EslamiRajat Mittal
May 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Mohammadali HedayatIman Borazjani
Nov 5, 2016·Journal of Biomechanical Engineering·Jonas LantzTino Ebbers
Apr 20, 2018·Frontiers in Cardiovascular Medicine·Giorgia Maria BosiGaetano Burriesci
Jan 7, 2021·Annals of Biomedical Engineering·Jorge Dueñas-PamplonaJorge Munoz-Paniagua
Mar 16, 2021·Frontiers in Physiology·Manuel García-VillalbaJuan C Del Álamo
Mar 24, 2021·Biomechanics and Modeling in Mechanobiology·Runxin FangZhiyong Li
Mar 27, 2021·Biomechanics and Modeling in Mechanobiology·Liuyang FengXiaoyu Luo
May 7, 2021·Computers in Biology and Medicine·Jorge Dueñas-PamplonaJosé Ramón López-Mínguez
Jun 26, 2021·Cardiovascular Engineering and Technology·Yue-Hin LokeLaura J Olivieri
Jul 15, 2021·Echocardiography·Martina AvesaniXavier Iriart

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