Hemodynamics of a pulsatile left ventricular assist device driven by a counterpulsation pump in a mock circulation

Artificial Organs
Ashraf W KhirJohn R Pepper

Abstract

The BCM (CardialCare, Minneapolis, MN, U.S.A.) is a pusher-plate pulsatile left ventricular assist device (LVAD) that is operated by counterpulsation pumps. The purpose of this work was to assess the fluid dynamics associated with operating the BCM in a mock circulation, and also to examine the similarities between hemodynamic parameters produced by this device in vitro and those produced by the left ventricle (LV) in vivo. The BCM was connected to a true size silicon rubber aorta and operated by an intra-aortic balloon pump. We examined the performance of the device at two system pressures (6.5 and 8 kPa); at three heart rates (60, 80, and 100 bpm); and at three pumping frequencies (1:1, 1:2, 1:3). Pressure and flow were measured in the upper descending aorta, and wave intensity analysis was used to calculate the peak intensity and energy of the compression and expansion waves. Pressure and flow waveforms produced by the BCM LVAD in vitro under different loading conditions were similar to those observed in vivo under similar loadings. Pusher-plate-type LVADs can produce compression and expansion waves similar to those generated by healthy LV in vivo.

References

Aug 1, 1990·Journal of Biomechanical Engineering·K H Parker, C J Jones
Jan 1, 1988·Heart and Vessels·K H ParkerD G Gibson
Aug 17, 2001·Journal of Biomechanics·A W KhirK H Parker
Nov 29, 2001·Clinical Science·A W KhirD G Gibson
Dec 4, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·A Undar
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Oct 3, 2003·The International Journal of Artificial Organs·S VandenbergheP Verdonck
Feb 17, 2005·Journal of Biomechanics·A W Khir, K H Parker

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Citations

Mar 9, 2007·Artificial Organs·Paul S Malchesky
Feb 14, 2008·Artificial Organs·Juan F del Cañizo, Juan Duarte
Jun 19, 2019·Artificial Organs·Mathias RebholzMarianne Schmid Daners
Oct 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Silje Ekroll JahrenStijn Vandenberghe
Jun 5, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J Christopher BouwmeesterPramod Bonde
Dec 31, 2008·The International Journal of Artificial Organs·G FerrariG Rakhorst
Sep 29, 2021·The International Journal of Artificial Organs·Femke CapponAshraf W Khir

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