PMID: 59000Jan 1, 1976

Hemodynamics of hyperthyroidism. The effects of autonomic nervous blocking and anti-thyroid drug treatment

Japanese Heart Journal
T Funatsu

Abstract

This work was intended to analyze the sympathetic and parasympathetic factors affecting the hemodynamics of hyperthyroidism. Seven patients with hyperthyroidism, diagnosed based on the determinations of BMR, 131I-uptake, T3-resin sponge uptake (T3-RSU), and serum level of thyroxine (T4) were subjected to the study. The hemo-dynamic estimation was done (1) at rest, (2) after vagus blocking by the injection of 0.04 mg/Kg b.wt. atropine and 0.2 mg/Kg b.wt. propranolol before (hyperthyroid state=H) and after (euthyroid state=E) anti-thyroid drug therapy. Cardiac output was measured by the dye-dilution method, and the valve was calculated according to the standard Hamilton formula. The following results were obtained. (1) The vagal tone is lower in H than in E, on the other hand, sympathetic beta-receptor tone is higher in H than in E. (2) The sympathetic alpha-receptor tone in H may be equivalent to that in E. (3) There might exist inotropic factors which affect the hemo-dynamics, other than autonomic nervous system in H.

Related Concepts

Atropen
Sympathetic Nerve Block
Autonomic Nervous System
Cardiac Output
Hemodynamics
Hyperthyroidism
Rexigen
Norepinephrine Receptors
Tachycardia
Goitrogens

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