Hemodynamics of the string phenomenon in the internal thoracic artery grafted to the left anterior descending artery with moderate stenosis

Journal of Biomechanics
Xi ZhaoZhou Zhao

Abstract

The internal thoracic artery is the choice of graft for coronary artery bypass grafting due to the excellent long-term patency. However internal thoracic artery graft failures still occur due to diffuse narrowing, known as the string phenomenon. Studies suggest that the string phenomenon is caused by competitive flow when the coronary stenosis is not serious, but the hemodynamics of the string phenomenon are still unclear. The purpose of this study is to clarify the hemodynamic characteristics of the string phenomenon. A patient-specific 3-dimensional model of the aortic arch and coronary arteries was reconstructed. A moderate stenosis was applied to the left anterior descending artery. The internal thoracic artery was used to bypass the stenosis. Two further 3D models were built to study the hemodynamics of the string phenomenon. A numerical study was performed by coupling the 3D artery model with 0-dimensional lumped parameter model of the cardiovascular system. The graft flow, native coronary flow, wall shear stress and oscillatory shear index were calculated and illustrated. Inverse flow and high oscillatory shear index appeared on the internal thoracic artery graft when the stenosis was moderate. High oscillatory shear ind...Continue Reading

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Citations

Aug 20, 2016·Biomechanics and Modeling in Mechanobiology·Bruno GuerciottiRoberto Scrofani
Jun 28, 2018·International Journal for Numerical Methods in Biomedical Engineering·Xinyang GeFuyou Liang
Apr 3, 2020·Journal of Cardiovascular Translational Research·Muhammad Owais KhanAlison L Marsden
Feb 6, 2017·Biomedical Engineering Online·Wenxin WangYoujun Liu
Mar 23, 2020·Biomechanics and Modeling in Mechanobiology·Zhuxiang XiongTinghui Zheng
Jul 16, 2021·Computer Methods and Programs in Biomedicine·Jincheng LiuYoujun Liu

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