Hemodynamics should be the primary approach to diagnosing, following, and managing pulmonary arterial hypertension

The Canadian Journal of Cardiology
Bradley A Maron

Abstract

Pulmonary arterial hypertension (PAH) is a highly morbid cardiopulmonary disease characterized by plexogenic pulmonary arteriole remodelling. Importantly, PAH severity correlates inversely with cardiac output and directly with pulmonary vascular resistance and right atrial pressure, illustrating the importance of accurately measured hemodynamics to define the clinical profile of patients. Currently available noninvasive technology offers only hemodynamic estimates. In contrast, right heart catheterization is the principle diagnostic procedure in PAH and is required to: (1) definitively exclude alternative pulmonary vascular diseases; and (2) quantify hemodynamics at baseline, after vasoreactivity testing, or in response to therapy to prognosticate outcome and guide therapeutic escalation.

References

Feb 1, 1996·The New England Journal of Medicine·R J BarstUNKNOWN Primary Pulmonary Hypertension Study Group
Jan 25, 2006·European Heart Journal·Steeve ProvencherGérald Simonneau
Dec 19, 2006·Journal of the American College of Cardiology·Marius M HoeperLewis J Rubin
Sep 15, 2009·The European Respiratory Journal·N GalièG Simonneau
Jun 1, 2011·European Heart Journal·Ana García-AlvarezJavier Sanz
Aug 24, 2012·Circulation. Cardiovascular Imaging·Alexander R OpotowskyPaul R Forfia
Sep 1, 2012·The European Respiratory Journal·Robert NaeijeRebecca Vanderpool
Sep 11, 2012·European Journal of Heart Failure·Elke PlatzAkshay S Desai
Sep 19, 2012·The Canadian Journal of Cardiology·Nancy Luo, John J Ryan
Jun 6, 2013·The American Journal of Cardiology·Alexander R OpotowskyPaul R Forfia
Jul 3, 2013·Circulation. Heart Failure·Bradley A MaronJayashri R Aragam
Jul 26, 2013·The New England Journal of Medicine·Hossein-Ardeschir GhofraniUNKNOWN PATENT-1 Study Group
Aug 30, 2013·The New England Journal of Medicine·Tomás PulidoUNKNOWN SERAPHIN Investigators
Dec 21, 2013·Journal of the American College of Cardiology·Marius M HoeperDavid B Badesch
Dec 21, 2013·Journal of the American College of Cardiology·Nazzareno GalièAnne Keogh
Apr 20, 2014·The European Respiratory Journal·Rudolf K F OliveiraJaquelina S Ota-Arakaki

❮ Previous
Next ❯

Citations

Aug 5, 2017·Scandinavian Cardiovascular Journal : SCJ·Joanna SälebyGöran Rådegran
Jan 19, 2020·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andriy O SamokhinBradley A Maron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.